{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:44:49Z","timestamp":1789497889674,"version":"build-2803163510"},"reference-count":45,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01 CX001553"],"award-info":[{"award-number":["I01 CX001553"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["F31HL163872"],"award-info":[{"award-number":["F31HL163872"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Dendritic cell subsets play unique roles in chronic obstructive pulmonary disease (COPD) pathogenesis. We demonstrated that conventional DC type 1 (cDC1) are decreased, leading to a predominant cDC2 population in the lungs of a clinically relevant murine model of cigarette smoke exposure. This drives naive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells toward IL-17 production and could play a role in the Th17\/Treg imbalance seen in COPD.\n                  <\/jats:p>","DOI":"10.1152\/ajplung.00138.2025","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T16:30:00Z","timestamp":1764606600000},"page":"L66-L76","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Predominant lung cDC2 phenotype in cigarette smoke-exposed mice favors polarization of IL-17-producing CD4\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1152","volume":"330","author":[{"given":"Dawit T.","family":"Mengistu","sequence":"first","affiliation":[{"name":"University of Michigan","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam S.","family":"Toma","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School and Michigan Medicine","place":["United States"]},{"name":"VA Ann Arbor Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5712-9161","authenticated-orcid":false,"given":"Benjamin C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Michigan","place":["United States"]},{"name":"VA Ann Arbor Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-4847","authenticated-orcid":false,"given":"Jeffrey L.","family":"Curtis","sequence":"additional","affiliation":[{"name":"University of Michigan","place":["United States"]},{"name":"University of Michigan Medical School and Michigan Medicine","place":["United States"]},{"name":"VA Ann Arbor Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3548-8133","authenticated-orcid":false,"given":"Christine M.","family":"Freeman","sequence":"additional","affiliation":[{"name":"University of Michigan","place":["United States"]},{"name":"University of Michigan Medical School and Michigan Medicine","place":["United States"]},{"name":"VA Ann Arbor Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00367.2020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092145"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2023-0175PS"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121087"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142132"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S167192"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.113"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.04.010"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00010407"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.804919"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.06.010"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096421"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0083"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201956"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200608-1113OC"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200904-0552OC"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4350"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranlsmed.3000154"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.05.016"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00971"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25307-x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.860915"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00322.2020"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2513OC"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ni1541"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(03)00113-4"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101819-025146"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091627"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.03.011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/ni1488"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1613"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-2028PP"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.106"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.09.001"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.731947"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3734"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6725"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838950"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-133967"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-183251"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4573"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.035"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02234-3"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1555235"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab185"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00138.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:58:16Z","timestamp":1769183896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00138.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1152\/ajplung.00138.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00138.2025","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}