{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:45:11Z","timestamp":1793385911203,"version":"4.5.0"},"reference-count":101,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL152101"],"award-info":[{"award-number":["HL152101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["REZNIK23Y3"],"award-info":[{"award-number":["REZNIK23Y3"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007049","name":"Evelyn F. McKnight Brain Research Foundation","doi-asserted-by":"publisher","award":["Gator NeuroScholars"],"award-info":[{"award-number":["Gator NeuroScholars"]}],"id":[{"id":"10.13039\/100007049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>The role of airway sympathetic nerves in regulating airway responses remains largely undefined. We demonstrated that chemical depletion of airway sympathetic nerves attenuates specific IL-13-induced airway deficits at the molecular, cellular, and functional level. Our data suggest that airway sympathetic nerves may represent novel therapeutic targets to alleviate some pathologic features due to type 2 (IL-13-mediated) airway inflammation.<\/jats:p>","DOI":"10.1152\/ajplung.00139.2025","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:40:27Z","timestamp":1757698827000},"page":"L524-L537","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Airway sympathectomy attenuates inflammation, transcriptional ratios of Muc5ac and Muc5b, and airway mechanic deficits in mice delivered intranasal IL-13"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-3337","authenticated-orcid":false,"given":"Pedro","family":"Trevizan-Ba\u00fa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Fagan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanil P.","family":"Amin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-9070","authenticated-orcid":false,"given":"Leah R.","family":"Reznikov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(03)00241-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.916"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.13.1.27"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.157315"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00142-2021"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_64"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2205PP"},{"key":"B9","volume-title":"StatPearls","author":"Chu R","year":"2024"},{"key":"B10","volume-title":"StatPearls","author":"Hsu E","year":"2024"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.01.039"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2014.08.008"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710196114"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0364OC"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1980.121.2.351"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90351-x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.2.426"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1042\/cs0630023"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1980.121.2.359"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/279551a0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.49.6.1027"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.2.457"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0279RC"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810902106"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201101-013MW"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.3.699"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(82)90030-3"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1986.134.5.1289"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1159\/000142658"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1159\/000143375"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.2.426"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90239-x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.002"},{"key":"B34","first-page":"493","volume":"138","author":"Pack R","year":"1984","journal-title":"J Anat"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501920"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1136\/thx.38.5.333"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0718"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903395"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay1497"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2258"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13864"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156091"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1392443"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1578553"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2261"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1172\/JCI123524"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0180OC"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1159\/000091391"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00119.2022"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00226.2023"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1272980"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166089"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-018-0091-0"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00557.2017"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00417.2018"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1323865"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5909"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.1.L181"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/all.13546"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12156"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2003.t01-1-01163.x"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39731"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29176"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79422"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00129"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807849200"},{"key":"B68","first-page":"33","volume":"70","author":"Valentijn JA","year":"1996","journal-title":"Eur J Cell Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0060OC"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(00)00209-7"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1975.0151"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2019.103358"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199801)25:1<45::AID-PPUL5>3.3.CO;2-M"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.05.013"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.3.1184"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140049"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i4.204"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01129.2003"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110614"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66510-2"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.07.001"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122475"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40173-5"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4874"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1159\/000233573"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abp9547"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2023.0445"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-049OC"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0405OC"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00162-13"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.2174\/1568010033484052"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3410\/B4-6"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12324"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.012"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4829"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00736"},{"key":"B97","doi-asserted-by":"publisher","unstructured":"Murray K, Cremin M, Tay EXY, Sanchez KR, Schreiber S, Brust-Mascher I, Leigh W, Ashfaq J, Gareau MG, Reardon C. Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation (Preprint). bioRxiv : 2025.02.12.637880, 2025. doi:10.1101\/2025.02.12.637880. 40027796","DOI":"10.1101\/2025.02.12.637880"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490240045034"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0528-y"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S282667"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00139.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:45:15Z","timestamp":1761054315000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00139.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":101,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1152\/ajplung.00139.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00139.2025","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}