{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:10:04Z","timestamp":1769191804792,"version":"3.49.0"},"reference-count":45,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01HL146821"],"award-info":[{"award-number":["NIH R01HL146821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL175464"],"award-info":[{"award-number":["R01HL175464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20TPA35490010"],"award-info":[{"award-number":["20TPA35490010"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25POST1366363"],"award-info":[{"award-number":["25POST1366363"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM131896"],"award-info":[{"award-number":["R35GM131896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2210040"],"award-info":[{"award-number":["W81XWH2210040"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23CDA1052265"],"award-info":[{"award-number":["23CDA1052265"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["ALA CA- 1374253"],"award-info":[{"award-number":["ALA CA- 1374253"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    No targeted interventions exist that improve the outcomes of patients with acute lung injury\/ARDS. A few studies investigated Na\n                    <jats:sup>+<\/jats:sup>\n                    and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels\/transporters for potential therapeutic intervention but with limited translational success. This study highlights the regulatory role of TREK-1 K\n                    <jats:sup>+<\/jats:sup>\n                    channels during HO+stretch\/mechanical ventilation-induced lung injury in ROS production, caspase activation, cytokine secretion, and explores the underlying TREK-1-mediated signaling mechanisms. These preclinical findings lay the groundwork for future rational drug design targeting TREK-1 channels.\n                  <\/jats:p>","DOI":"10.1152\/ajplung.00143.2025","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:10:42Z","timestamp":1763489442000},"page":"L49-L65","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-7019","authenticated-orcid":false,"given":"Nairrita","family":"Majumder","sequence":"first","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Lopez","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aren","family":"Kasparian","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kushal","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Zhong","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-3784","authenticated-orcid":false,"given":"Marina","family":"Angelini","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Zyrianova","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-9814","authenticated-orcid":false,"given":"Riccardo","family":"Olcese","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]},{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-0199","authenticated-orcid":false,"given":"Andreas","family":"Schwingshackl","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000148231.04642.8d"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00619.2002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00570.2001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.5.1220"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.08.010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.4.3173"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01963"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.07.004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00539.2011"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00072.2010"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00078.2011"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000603"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2023-0320MA"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.223"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00643"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00299.2012"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.97054"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78886-y"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113632"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.1.97"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00116.2022"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00121.2017"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7382.219"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00313.2023"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003947"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.318339"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.1.H114"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2020"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2011.08.005"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1126\/science.2173861"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110636"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152859"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.729094"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nature22988"},{"key":"B35","doi-asserted-by":"publisher","unstructured":"Deal PE, Lee H, Mondal A, Lolicato M, de Mendonca PRF, Black H, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL Jr. Development of covalent chemogenetic K(2P) channel activators. bioRxiv: 2023.10.15.561774, 2023. doi:10.1101\/2023.10.15.561774. 37905049","DOI":"10.1101\/2023.10.15.561774"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.078592"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005910"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.012"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0910-0"},{"key":"B40","first-page":"530","volume":"5","author":"Schwingshackl A","year":"2013","journal-title":"Am J Transl Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01644"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44050150"},{"key":"B43","first-page":"123","volume":"13","author":"Pongor S","year":"1978","journal-title":"Acta Biochim Biophys Acad Sci Hung"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/srep32311"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03502-7"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00143.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:58:21Z","timestamp":1769183901000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00143.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1152\/ajplung.00143.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00143.2025","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}