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To understand the in vivo role of RELM-\u03b2, we delivered recombinant murine RELM-\u03b2 intratracheally to na\u00efve mice. RELM-\u03b2 induced dose-dependent leukocyte accumulation (most prominently involving macrophages) and goblet cell hyperplasia. The most prominent effect induced by RELM-\u03b2 was increased perivascular and peribronchial collagen deposition. Mice genetically deficient in RELM-\u03b2 had reduced accumulation of collagen and goblet cell hyperplasia in an experimental model of allergic airway inflammation. In vitro experiments demonstrated that RELM-\u03b2 had fibroblast motogenic activity. These results identify RELM-\u03b2 as a Th2-associated cytokine with potent inflammatory and remodeling activity.<\/jats:p>","DOI":"10.1152\/ajplung.00147.2007","type":"journal-article","created":{"date-parts":[[2007,6,2]],"date-time":"2007-06-02T01:18:27Z","timestamp":1180747107000},"page":"L305-L313","source":"Crossref","is-referenced-by-count":53,"title":["Resistin-like molecule-\u03b2 is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung"],"prefix":"10.1152","volume":"293","author":[{"given":"Anil","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Schlotman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos 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