{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:36:18Z","timestamp":1793036178124,"version":"4.5.0"},"reference-count":55,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL158779"],"award-info":[{"award-number":["R01HL158779"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"HHS | NIH | NIAID | Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI172873"],"award-info":[{"award-number":["R01AI172873"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016229","name":"HHS | NIH | NCI | CCR | Basic Research Laboratory","doi-asserted-by":"publisher","award":["P20GM135004"],"award-info":[{"award-number":["P20GM135004"]}],"id":[{"id":"10.13039\/100016229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>This work defines multiple roles of mature neutrophils in regulation of the immune response to, and the induction of acute lung injury after, SARS-CoV-2 infection. This research defines neutrophil exocytosis as a therapeutic target to prevent lung injury following SARS-CoV-2 infection.<\/jats:p>","DOI":"10.1152\/ajplung.00155.2026","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:07:00Z","timestamp":1791220020000},"page":"L543-L555","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil control of immune cell recruitment and acute lung injury in SARS-CoV-2-infected mice"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-3286","authenticated-orcid":false,"given":"Kenneth R.","family":"McLeish","sequence":"first","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]},{"name":"Degranin Therapeutics, LLC","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi J.","family":"Rane","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]},{"name":"Degranin Therapeutics, LLC","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-9901","authenticated-orcid":false,"given":"Michelle T.","family":"Barati","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Hu","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Tandon","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-0538","authenticated-orcid":false,"given":"Charles D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adlen A.","family":"Asta","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-9004","authenticated-orcid":false,"given":"Lalit","family":"Batra","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chithra C.","family":"Sreenivasan","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon D.","family":"Gabbard","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-0271","authenticated-orcid":false,"given":"Silvia M.","family":"Uriarte","sequence":"additional","affiliation":[{"name":"University of Louisville","place":["United States"]},{"name":"Degranin Therapeutics, LLC","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-8400","authenticated-orcid":false,"given":"Jiapeng","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]},{"name":"Degranin Therapeutics, LLC","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]},{"name":"University of Louisville School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine","place":["United States"]},{"name":"University of Louisville School of Medicine","place":["United States"]},{"name":"Degranin Therapeutics, LLC","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2510226"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04705-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1363572"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038922"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000911"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108590"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100291"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.148435"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102206"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.002"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13175"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.652470"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.879686"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003568"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309880"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01343-z"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201012"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007008"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00113.2024"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2017"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00160"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00550.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2018"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/path.5221"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902497"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-57"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012449"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017618"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1013969"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2020.118"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI188222"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04630-3"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003112"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1159\/000345992"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0210ST"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/EP091682"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16596-9"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.002"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI0120-645R"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139634"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000190113.31027.d5"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90546.2008"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913516524"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109478"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2562"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080201"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003188"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70098"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.2741\/s43"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115072"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00962"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00138"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00173207"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318282c9a1"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00155.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:40:25Z","timestamp":1793032825000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00155.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,1]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1152\/ajplung.00155.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00155.2026","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,11,1]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}