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In our experiments, mice carrying the R117H Cftr mutation have significantly reduced airway inflammatory responses to both LPS and flagellin when treated with CDDO before inflammatory challenge. Anti-inflammatory effects observed include reduced airway neutrophilia, reduced concentrations of proinflammatory cytokines and chemokines, and reduced weight loss. Our findings with the synthetic triterpenoids in multiple cell culture models of CF human airway epithelia agree with effects previously described in other disease models (e.g., neoplastic cells). These include the ability to reduce NF-\u03baB activation while increasing nuclear factor erythroid-related factor 2 (Nrf2) activity. As these two signaling pathways appear to be pivotal in regulating the net inflammatory response in the CF airway, these compounds are a promising potential anti-inflammatory therapy for CF lung disease. <\/jats:p>","DOI":"10.1152\/ajplung.00171.2009","type":"journal-article","created":{"date-parts":[[2009,8,22]],"date-time":"2009-08-22T02:06:08Z","timestamp":1250906768000},"page":"L828-L836","source":"Crossref","is-referenced-by-count":34,"title":["The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease"],"prefix":"10.1152","volume":"297","author":[{"given":"David P.","family":"Nichols","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assem G.","family":"Ziady","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and 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