{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:13:56Z","timestamp":1780992836481,"version":"3.54.1"},"reference-count":49,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p> Invasive mechanical ventilation and oxygen toxicity are postnatal contributors to chronic lung disease of prematurity, also known as bronchopulmonary dysplasia (BPD). Cyfra 21-1 is a soluble fragment of cytokeratin 19, which belongs to the cytoskeleton stabilizing epithelial intermediate filaments. As a biomarker of structural integrity, Cyfra 21-1 might be associated with airway injury and lung hypoplasia in neonates. Serum Cyfra 21-1 concentrations for 80 preterm and 80 healthy term newborns were measured within 48 h after birth. Preterm infants with the combined endpoint BPD\/mortality had significantly higher Cyfra 21-1 levels compared with those without fulfilling BPD\/mortality criteria ( P = 0.01). Also, severe RDS (&gt;grade III) was associated with higher Cyfra levels ( P = 0.01). Total duration of oxygen therapy was more than five times longer in neonates with high Cyfra 21-1 levels ( P = 0.01). Infants with higher Cyfra 21-1 values were more likely to receive mechanical ventilation (50% vs. 17.5%). However, the duration of mechanical ventilation was similar between groups. The median Cyfra value was 1.93 ng\/mL (IQR: 1.68\u20132.53 ng\/mL) in healthy term neonates and 8.5 ng\/mL (IQR: 3.6\u201316.0 ng\/mL) in preterm infants. Using ROC analysis, we calculated a Cyfra cutoff &gt; 8.5 ng\/mL to predict BPD\/death with an AUC of 0.795 ( P = 0.004), a sensitivity of 88.9%, and a specificity of 55%. Mortality was predicted with a cutoff &gt; 17.4 ng\/mL (AUC: 0.94; P = 0.001), a sensitivity of 100%, and a specificity of 84%. These findings suggest that Cyfra 21-1 concentration might be useful to predict poor outcome in premature infants. <\/jats:p>","DOI":"10.1152\/ajplung.00176.2021","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T12:01:04Z","timestamp":1632916864000},"page":"L1036-L1043","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased circulating cytokeratin 19 fragment levels in preterm neonates receiving mechanical ventilation are associated with poor outcome"],"prefix":"10.1152","volume":"321","author":[{"given":"Sarah","family":"Panahabadi","sequence":"first","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, Bonn, Germany"},{"name":"Department of Neuroradiology, University Hospital Bonn, Bonn, 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