{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:30:22Z","timestamp":1774564222582,"version":"3.50.1"},"reference-count":44,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:p>The potential role of airway interleukin-5 (IL-5) expression in eliciting mucus production was demonstrated in a pulmonary IL-5 transgenic mouse model (NJ.1726) in which naive transgenic mice display comparable levels of airway mucus relative to allergen-sensitized and -challenged wild-type mice. The intrinsic mucus accumulation of NJ.1726 was abolished in compound transgenic-gene knockout mice deficient of either CD4<jats:sup>+<\/jats:sup>cells [NJ.1726\/CD4(\u2212\/\u2212)] or \u03b1\u03b2 T cell receptor-positive (TCR<jats:sup>+<\/jats:sup>) cells [NJ.1726\/\u03b1\u03b2 TCR(\u2212\/\u2212)]. In addition, mucus production in naive NJ.1726 was inhibited by &gt;90% after administration of the soluble anti-IL-4 receptor \u03b1-subunit antagonist. The loss of mucus production in NJ.1726\/CD4(\u2212\/\u2212), NJ.1726\/\u03b1\u03b2 TCR(\u2212\/\u2212), and anti-IL-4 receptor \u03b1-subunit antagonist-treated mice occurred notwithstanding the significant pulmonary eosinophilia and expansion of airway B cells induced by ectopic IL-5 expression. Furthermore, the loss of mucus accumulation occurred in these mice despite elevated levels of airway and peripheral IL-5, indicating that IL-5 does not directly induce goblet cell metaplasia and mucus production. Thus pulmonary expression of IL-5 alone is capable of inducing CD4<jats:sup>+<\/jats:sup>T cell-dependent goblet cell metaplasia, apparently mediated by IL-4 receptor \u03b1-subunit-ligand interactions, and represents a previously unrecognized novel pathway for augmenting allergen-induced mucus production.<\/jats:p>","DOI":"10.1152\/ajplung.00195.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:16:48Z","timestamp":1425413808000},"page":"L1066-L1074","source":"Crossref","is-referenced-by-count":32,"title":["CD4<sup>+<\/sup>T cell-dependent airway mucus production occurs in response to IL-5 expression in lung"],"prefix":"10.1152","volume":"282","author":[{"given":"J. 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