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Interestingly, early imaging studies documented that pulmonary vascular thickening was specifically associated with COVID-19 pneumonia, implying a potential tropism of the virus for the pulmonary vasculature. Moreover, SARS-CoV-2 infection is associated with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, DNA damage, and lung coagulopathy promoting endothelial dysfunction and microthrombosis. These features are strikingly similar to what is seen in pulmonary vascular diseases. Although the consequences of COVID-19 on the pulmonary circulation remain to be explored, several viruses have been previously thought to be involved in the development of pulmonary vascular diseases. Patients with preexisting pulmonary vascular diseases also appear at increased risk of morbidity and mortality. The present article reviews the molecular factors shared by coronavirus infection and pulmonary vasculature defects, and the clinical relevance of pulmonary vascular alterations in the context of COVID-19. <\/jats:p>","DOI":"10.1152\/ajplung.00195.2020","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T20:15:13Z","timestamp":1592424913000},"page":"L277-L288","source":"Crossref","is-referenced-by-count":136,"title":["Novel insights on the pulmonary vascular consequences of COVID-19"],"prefix":"10.1152","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-6445","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Potus","sequence":"first","affiliation":[{"name":"Pulmonary Hypertension Research Group, Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et Pneumologie de Quebec City, Quebec, Canada"},{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Research Centre, Laval 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