{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:49:57Z","timestamp":1793674197402,"version":"4.5.1"},"reference-count":45,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL158507"],"award-info":[{"award-number":["P01 HL158507"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL128370"],"award-info":[{"award-number":["HL128370"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL128192"],"award-info":[{"award-number":["P01 HL128192"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL146601"],"award-info":[{"award-number":["HL146601"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:p>The PCD airway epithelium does not optimally clear antigens, and antigen exposure can lead to NO oxidation and nitrosative stress. Oxidation caused by antigen stasis could represent a therapeutic target in PCD, and there are convenient monitoring biomarkers.<\/jats:p>","DOI":"10.1152\/ajplung.00208.2022","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T04:02:03Z","timestamp":1707192123000},"page":"L468-L476","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia"],"prefix":"10.1152","volume":"326","author":[{"given":"Benjamin","family":"Gaston","sequence":"first","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-0482","authenticated-orcid":false,"given":"Laura A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Davis","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Saunders","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Daniels","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-1948","authenticated-orcid":false,"given":"Amjad","family":"Horani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Brody","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Giddings","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-588X","authenticated-orcid":false,"given":"Nadzeya","family":"Marozkina","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3233\/TRD-190036"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00453-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23304"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-365OC"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.11.021"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00020.2019"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021113-170352"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9807044"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-125-7_8"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101146"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.01.024"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1021\/j100658a001"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117607"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14158"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.003"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62288-2"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04736-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2961"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102781200"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110708"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/106507"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.10089"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.01.052"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051629498"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00965-2016"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-020-01171-2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0548OC"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11226791"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.11.013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200311-1516OC"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.01.029"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202211-2096OC"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24192"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13870"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94782-5"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2106006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/1479972317694621"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909128107"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5844"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.4.7695916"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.10.6911"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.749028"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.664854"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90002-7"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25440"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00208.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T15:35:49Z","timestamp":1712331349000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00208.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,1]]}},"alternative-id":["10.1152\/ajplung.00208.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00208.2022","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]},"assertion":[{"value":"2022-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}