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Animals were administered levosimendan alone ( group L), levosimendan after pretreatment with a K<jats:sub>ATP<\/jats:sub>channel blocker (glibenclamide, group LG), glibenclamide only ( group G), or solvent alone (dextrose, group C). Airway resistance (R<jats:sub>aw<\/jats:sub>), tissue damping, and elastance were determined by forced oscillations under baseline conditions and following provocation tests with intravenous methacholine (MCh). Cardiac output (CO) was assessed by transpulmonary thermodilution. The same sequence of measurements was then repeated during intravenous infusion of levosimendan in groups L and LG or glucose in groups G and C. Sham treatments in groups C and G had no effect on lung responsiveness. However, levosimendan treatment in group L elevated CO and inhibited the MCh-induced airway responses [R<jats:sub>aw<\/jats:sub>changes of 87.8 \u00b1 83% (SD) vs. 24.4 \u00b1 16% at 4 \u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>MCh, P &lt; 0.001], and in G (35.2 \u00b1 12.7 vs. 25.2 \u00b1 12.9%, P &lt; 0.05). The preventive affect of levosimendan against lung constriction vanished in the LG group. Levosimendan exerts a K<jats:sub>ATP<\/jats:sub>-mediated potential to prevent bronchoconstriction and may prohibit adverse lung peripheral changes both in the small bronchi and the pulmonary parenchyma. The identification of a further pleiotropic property of levosimendan that is related to the pulmonary system is of particular importance for patients with decreased cardiorespiratory reserves for which simultaneous circulatory support is complemented with prevention of adverse respiratory events.<\/jats:p>","DOI":"10.1152\/ajplung.00213.2017","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:10:47Z","timestamp":1503619847000},"page":"L950-L956","source":"Crossref","is-referenced-by-count":11,"title":["Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits"],"prefix":"10.1152","volume":"313","author":[{"given":"Barna","family":"Babik","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, University of Szeged, Szeged, Hungary; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam 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