{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:27:31Z","timestamp":1791613651754,"version":"4.3.4"},"reference-count":66,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23CDA1042910"],"award-info":[{"award-number":["23CDA1042910"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL144943"],"award-info":[{"award-number":["R01HL144943"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL157583"],"award-info":[{"award-number":["RO1HL157583"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-17-1-0503"],"award-info":[{"award-number":["W81XWH-17-1-0503"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5 IK2 BX 003841"],"award-info":[{"award-number":["5 IK2 BX 003841"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19TPA34910157"],"award-info":[{"award-number":["19TPA34910157"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p>We developed a mice model of \u201cpost-deployment respiratory syndrome\u201d (PDRS), a condition in Veterans with unexplained exertional dyspnea. Our model successfully recapitulates many of the pathological and physiological features of the syndrome, revealing involvement of the ROS-isoLGs-Sirt3-SOD2 pathway in pulmonary vasculature pathology. Our study provides additional knowledge about effects and long-term consequences of sulfur dioxide exposure on the respiratory system, serving as a valuable tool for future PDRS research.<\/jats:p>","DOI":"10.1152\/ajplung.00239.2023","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T04:01:26Z","timestamp":1709006486000},"page":"L539-L550","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Repetitive sulfur dioxide exposure in mice models post-deployment respiratory syndrome"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-0516","authenticated-orcid":false,"given":"Sergey S.","family":"Gutor","sequence":"first","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo I.","family":"Salinas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Emory University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M. R.","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Gokey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgii","family":"Vasiukov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6004-0202","authenticated-orcid":false,"given":"James D.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn C.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Dikalova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-5235","authenticated-orcid":false,"given":"Bradley W.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-6184","authenticated-orcid":false,"given":"Sergey I.","family":"Dikalov","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliy V.","family":"Polosukhin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.17226\/25837","volume-title":"Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations","author":"National Academies, Sciences, and Engineering; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations.","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.713"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxu009"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201904-344WS"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.01.024"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101388"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001757"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.10.031"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/07482337211033136"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1039\/b618041h"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/08958370304476"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8564209"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1039\/C29710000339"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535437"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34633-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2003.10.007"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107418"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310933"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2022.205.1_MeetingAbstracts.A5490"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2023.207.1_MeetingAbstracts.A6170"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics2010018"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17915-w"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28261-9"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1522ST"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-00344-9"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000258594.87211.6b"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.214601"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1086\/683811"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201306-1086OC"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2133OC"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.014"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.136678"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112024"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315767"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.02.014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(199607)16:4<365::AID-JAT360>3.0.CO;2-H"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01489-8"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1080\/15287398709531008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03053.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126656"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610770104"},{"key":"B42","first-page":"324","volume":"192","author":"Stratmann U","year":"1991","journal-title":"Zentralbl Hyg Umweltmed"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.3_Supplement.16S-a"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.12.027"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2010.09.057"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1159\/000194195"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.06.089"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.08.018"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.021101191"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1159\/000079164"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geh058"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05528.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0176-1617(96)80258-6"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s13580-017-0053-0"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0360OC"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2976957"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmv013"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45922"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-023-01801-w"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1177\/1091581816682225"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301141"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1080\/08958370701271373"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1961.10662922"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100003"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.105030"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120024"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00239.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T12:53:48Z","timestamp":1713963228000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00239.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["10.1152\/ajplung.00239.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00239.2023","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.15.540867","asserted-by":"object"}]},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]},"assertion":[{"value":"2023-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}