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Gerstner Jr. Scholars"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:p>Asthma, a common disorder associated with airway inflammation and hyperresponsiveness, remains a significant clinical burden in need of novel therapeutic strategies. Patients are increasingly seeking complementary and alternative medicine approaches to control their symptoms, including the use of natural products. Ginger, a natural product that we previously demonstrated acutely relaxes airway smooth muscle (ASM), has long been reported to possess anti-inflammatory properties, although a precise mechanistic understanding is lacking. In these studies, we demonstrate that chronic administration of whole ginger extract or 6-shogaol, a bioactive component of ginger, mitigates in vivo house dust mite antigen-mediated lung inflammation in mice. We further show that this decrease in inflammation is associated with reduced in vivo airway responsiveness. Utilizing in vitro studies, we demonstrate that 6-shogaol augments cAMP concentrations in CD4 cells, consistent with phosphodiesterase inhibition, and limits the induction of nuclear factor-\u03baB signaling and the production of proinflammatory cytokines in activated CD4 cells. Sustained elevations in cAMP concentration are well known to inhibit effector T cell function. Interestingly, regulatory T cells (Tregs) utilize cAMP as a mediator of their immunosuppressive effects, and we demonstrate here that 6-shogaol augments the Treg polarization of na\u00efve CD4 cells in vitro. Taken together with previous reports, these studies suggest that ginger and 6-shogaol have the potential to combat asthma via two mechanisms: acute ASM relaxation and chronic inhibition of inflammation.<\/jats:p>","DOI":"10.1152\/ajplung.00249.2019","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T15:47:02Z","timestamp":1575474422000},"page":"L296-L303","source":"Crossref","is-referenced-by-count":62,"title":["Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model"],"prefix":"10.1152","volume":"318","author":[{"given":"Gene T.","family":"Yocum","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie J.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vagelos College of Physicians and 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