{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:51:57Z","timestamp":1785527517472,"version":"3.56.0"},"reference-count":84,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"Flatley Foundation"},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["STANTO19G0"],"award-info":[{"award-number":["STANTO19G0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["STANTO20P0"],"award-info":[{"award-number":["STANTO20P0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["STANTO23R0"],"award-info":[{"award-number":["STANTO23R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["STANTO19R0"],"award-info":[{"award-number":["STANTO19R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["DRUMM15R0\/CFF"],"award-info":[{"award-number":["DRUMM15R0\/CFF"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["CFF HODGES19R1"],"award-info":[{"award-number":["CFF HODGES19R1"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK117469"],"award-info":[{"award-number":["P30 DK117469"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL151385"],"award-info":[{"award-number":["R01 HL151385"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:p> Our findings show that extracellular vesicles secreted by primary human bronchial epithelial cells significantly reduce Pseudomonas aeruginosa burden, inflammation, and weight loss in a cystic fibrosis mouse model of infection. <\/jats:p>","DOI":"10.1152\/ajplung.00253.2023","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T09:00:28Z","timestamp":1702371628000},"page":"L164-L174","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Extracellular vesicles secreted by primary human bronchial epithelial cells reduce <i>Pseudomonas aeruginosa<\/i> burden and inflammation in cystic fibrosis mouse lung"],"prefix":"10.1152","volume":"326","author":[{"given":"Sharanya","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanna","family":"Barnaby","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda B.","family":"Nymon","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-983X","authenticated-orcid":false,"given":"Douglas J.","family":"Taatjes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Center for Biomedical Shared Resources, Larner College of Medicine, University of Vermont, Burlington, Vermont, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9236-7907","authenticated-orcid":false,"given":"Thomas J.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-407X","authenticated-orcid":false,"given":"Bruce A.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1193-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01744.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120562"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2715"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00326.2014"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010020"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00373.2016"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02146"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/children9081258"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10030338"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1505864"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902734116"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.995640"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnx121"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2022.105461"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200703-044BR"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24129"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-011-0113-6"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00243"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00173210"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/ni1056"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00071405"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00106013"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176379"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2010.05.003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/genes12071010"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061487"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.593160"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1042\/BST20200788"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.687632"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005672"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1977767"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01028"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-017-0355-1"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy554"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00377"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217723166"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105370118"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.94"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1535594"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056709"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00163414"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.2174\/1566523219666190719100526"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-187-6:495"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9901043"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46555-4"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-125-7_8"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00621.2020"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97033-9"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0170OC"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74135"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22967"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00127.2003"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092141999"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0058-2"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0725-2"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500973200"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4236\/scd.2013.32019"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.287"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801534"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201410-1765OC"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-0990OC"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-211576"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12124"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004315"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0170OC"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002655"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15700"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2906-z"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20162"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.588"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.107891"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90063-7"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00150.2022"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-120-8_19"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01475"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.10.017"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.41"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-016-0068-0"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.12.001"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00253.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T18:05:01Z","timestamp":1706205901000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00253.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,1]]}},"alternative-id":["10.1152\/ajplung.00253.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00253.2023","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}