{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:41:00Z","timestamp":1785890460818,"version":"3.56.0"},"reference-count":20,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["WEISS15XX0"],"award-info":[{"award-number":["WEISS15XX0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["WEISS16GO"],"award-info":[{"award-number":["WEISS16GO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL123004"],"award-info":[{"award-number":["HL123004"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, Blood Institute","doi-asserted-by":"crossref","award":["HL126456"],"award-info":[{"award-number":["HL126456"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, Blood Institute","doi-asserted-by":"crossref","award":["HHSN268201000008"],"award-info":[{"award-number":["HHSN268201000008"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Respiratory Society Respire 3 Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:p> Mesenchymal stromal (stem) cells (MSCs) are increasingly demonstrated to ameliorate experimentally induced lung injuries through disease-specific anti-inflammatory actions, thus suggesting that different in vivo inflammatory environments can influence MSC actions. To determine the effects of different representative inflammatory lung conditions, human bone marrow\u2013derived MSCs (hMSCs) were exposed to in vitro culture conditions from bronchoalveolar lavage fluid (BALF) samples obtained from patients with either the acute respiratory distress syndrome (ARDS) or with other lung diseases including acute respiratory exacerbations of cystic fibrosis (CF) (non-ARDS). hMSCs were subsequently assessed for time- and BALF concentration\u2013dependent effects on mRNA expression of selected pro- and anti-inflammatory mediators, and for overall patterns of gene and mRNA expression. Both common and disease-specific patterns were observed in gene expression of different hMSC mediators, notably interleukin (IL)-6. Conditioned media obtained from non-ARDS BALF-exposed hMSCs was more effective in promoting an anti-inflammatory phenotype in monocytes than was conditioned media from ARDS BALF-exposed hMSCs. Neutralizing IL-6 in the conditioned media promoted generation of anti-inflammatory monocyte phenotype. This proof of concept study suggest that different lung inflammatory environments potentially can alter hMSC behaviors. Further identification of these interactions and the driving mechanisms may influence clinical use of MSCs for treating lung diseases. <\/jats:p>","DOI":"10.1152\/ajplung.00263.2019","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T14:53:28Z","timestamp":1569423208000},"page":"L823-L831","source":"Crossref","is-referenced-by-count":47,"title":["Lung inflammatory environments differentially alter mesenchymal stromal cell behavior"],"prefix":"10.1152","volume":"317","author":[{"given":"Soraia C.","family":"Abreu","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont"},{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rolandsson Enes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont"},{"name":"Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Dearborn","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D.","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cla\u00fadia C.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Critical Care Medicine and the Keenan Research Center for Biomedical Science, St. Michael\u2019s Hospital, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Wargo","sequence":"additional","affiliation":[{"name":"Department of Microbial and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda F.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Loi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"DeSarno","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamuru","family":"Ashikaga","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana A.","family":"Antunes","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia R. 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