{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:38:44Z","timestamp":1761709124583},"reference-count":77,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:p> Acute exposure to ozone (O<jats:sub>3<\/jats:sub>), an air pollutant, causes pulmonary inflammation, airway epithelial desquamation, and airway hyperresponsiveness (AHR). Pro-inflammatory cytokines\u2014including IL-6 and ligands of chemokine (C-X-C motif) receptor 2 [keratinocyte chemoattractant (KC) and macrophage inflammatory protein (MIP)-2], TNF receptor 1 and 2 (TNF), and type I IL-1 receptor (IL-1\u03b1 and IL-1\u03b2)\u2014promote these sequelae. Human resistin, a pleiotropic hormone and cytokine, induces expression of IL-1\u03b1, IL-1\u03b2, IL-6, IL-8 (the human ortholog of murine KC and MIP-2), and TNF. Functional differences exist between human and murine resistin; yet given the aforementioned observations, we hypothesized that murine resistin promotes O<jats:sub>3<\/jats:sub>-induced lung pathology by inducing expression of the same inflammatory cytokines as human resistin. Consequently, we examined indexes of O<jats:sub>3<\/jats:sub>-induced lung pathology in wild-type and resistin-deficient mice following acute exposure to either filtered room air or O<jats:sub>3<\/jats:sub>. In wild-type mice, O<jats:sub>3<\/jats:sub> increased bronchoalveolar lavage fluid (BALF) resistin. Furthermore, O<jats:sub>3<\/jats:sub> increased lung tissue or BALF IL-1\u03b1, IL-6, KC, TNF, macrophages, neutrophils, and epithelial cells in wild-type and resistin-deficient mice. With the exception of KC, which was significantly greater in resistin-deficient compared with wild-type mice, no genotype-related differences in the other indexes existed following O<jats:sub>3<\/jats:sub> exposure. O<jats:sub>3<\/jats:sub> caused AHR to acetyl-\u03b2-methylcholine chloride (methacholine) in wild-type and resistin-deficient mice. However, genotype-related differences in airway responsiveness to methacholine were nonexistent subsequent to O<jats:sub>3<\/jats:sub> exposure. Taken together, these data demonstrate that murine resistin is increased in the lungs of wild-type mice following acute O<jats:sub>3<\/jats:sub> exposure but does not promote O<jats:sub>3<\/jats:sub>-induced lung pathology. <\/jats:p>","DOI":"10.1152\/ajplung.00270.2015","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T03:58:09Z","timestamp":1442635089000},"page":"L1174-L1185","source":"Crossref","is-referenced-by-count":8,"title":["Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure"],"prefix":"10.1152","volume":"309","author":[{"given":"Shehla S.","family":"Razvi","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy B.","family":"Richards","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhan","family":"Malik","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Cromar","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger E.","family":"Price","sequence":"additional","affiliation":[{"name":"Comparative Pathology Laboratory, Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia S.","family":"Bell","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance L.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal Y.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine J.","family":"Cockerill","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, Texas;"},{"name":"Pediatric Research Center, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas;"},{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas; 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