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In general, BN rats sensitized by either subcutaneous or intratracheal routes exhibited increased pulmonary allergy compared with Sprague-Dawley (SD) and Lewis (L) rats. Multiple intratracheal allergen exposures incrementally increased HDM-specific immune function in BN rats but progressively decreased eosinophil recruitment and markers of lung injury. SD rats had more moderate responses, whereas L rats were relatively unresponsive. Because BN rats developed stronger clinical hallmarks of allergic asthma under various immunization regimes compared with SD and L rats, we conclude that the BN is the most appropriate strain for studying allergic asthma-like responses in rats. Phenotypic differences in response to HDM were associated with differences in the Th1\/Th2 cytokine balance and antioxidant capacity.<\/jats:p>","DOI":"10.1152\/ajplung.00287.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:20:51Z","timestamp":1425396051000},"page":"L588-L598","source":"Crossref","is-referenced-by-count":19,"title":["Phenotypic comparison of allergic airway responses to house dust mite in three rat strains"],"prefix":"10.1152","volume":"284","author":[{"given":"Pramila","family":"Singh","sequence":"first","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine, Raleigh 27606; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Daniels","sequence":"additional","affiliation":[{"name":"National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell W.","family":"Winsett","sequence":"additional","affiliation":[{"name":"National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Richards","sequence":"additional","affiliation":[{"name":"National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Doerfler","sequence":"additional","affiliation":[{"name":"National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Hatch","sequence":"additional","affiliation":[{"name":"National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Adler","sequence":"additional","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine, Raleigh 27606; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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