{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:50:12Z","timestamp":1793379012243,"version":"4.5.0"},"reference-count":16,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"GlaxoSmithKline"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014780","name":"Longfonds","doi-asserted-by":"publisher","award":["3.2.09.081JU"],"award-info":[{"award-number":["3.2.09.081JU"]}],"id":[{"id":"10.13039\/501100014780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["5.1.14.020"],"award-info":[{"award-number":["5.1.14.020"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["5.1.14.020"],"award-info":[{"award-number":["5.1.14.020"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["3.2.09.081JU"],"award-info":[{"award-number":["3.2.09.081JU"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p>The IL-33\/IL-1RL1 pathway stands as a formidable genetic predisposition for asthma, with ongoing clinical developments of various drugs designed to mitigate its influence in patients with asthma. The absence of a transcriptomic reaction to IL-33 within the bronchial epithelium holds significance in the pursuit of identifying biomarkers that can aid in pinpointing those individuals who would derive the greatest benefit from therapies targeting the IL-33 pathway.<\/jats:p>","DOI":"10.1152\/ajplung.00298.2023","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T04:01:11Z","timestamp":1701748871000},"page":"L65-L70","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-4540","authenticated-orcid":false,"given":"Akshaya Keerthi","family":"Saikumar Jayalatha","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-871X","authenticated-orcid":false,"given":"Marnix R.","family":"Jonker","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes A.","family":"Carpaij","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-7340","authenticated-orcid":false,"given":"Maarten","family":"van den Berge","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen X.","family":"Affleck","sequence":"additional","affiliation":[{"name":"Immunology Research Unit, GlaxoSmithkline, Stevenage, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-3252","authenticated-orcid":false,"given":"Gerard H.","family":"Koppelman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-6521","authenticated-orcid":false,"given":"Martijn C.","family":"Nawijn","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.25"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107847"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.09.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006659"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.028"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.051"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30363-5"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87871"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.023"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01286-2020"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100300"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.044"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0468-5"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903818"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03867.x"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00298.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:34:17Z","timestamp":1704296057000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00298.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,1]]}},"alternative-id":["10.1152\/ajplung.00298.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00298.2023","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]},"assertion":[{"value":"2023-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}