{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:14:22Z","timestamp":1791951262060,"version":"4.3.4"},"reference-count":21,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["S2022\/BMD-7245"],"award-info":[{"award-number":["S2022\/BMD-7245"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"EC | Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["No. 847635"],"award-info":[{"award-number":["No. 847635"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2019-107363RB-I00"],"award-info":[{"award-number":["PID2019-107363RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2020-117939RB-I00"],"award-info":[{"award-number":["PID2020-117939RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p>Severe vitamin D deficiency is very prevalent in patients with pulmonary arterial hypertension. We show that addition of vitamin D to the standard PDE5 inhibitor tadalafil increases its therapeutic efficacy in pulmonary hypertensive rats that were deficient in vitamin D.<\/jats:p>","DOI":"10.1152\/ajplung.00319.2024","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T11:50:51Z","timestamp":1736423451000},"page":"L253-L259","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D as an add-on therapy to phosphodiesterase-5 inhibitor in experimental pulmonary arterial hypertension"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-436X","authenticated-orcid":false,"given":"Rui","family":"Ad\u00e3o","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]},{"name":"University of Porto, Alameda Prof. Hern\u00e2ni Monteiro","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-8456","authenticated-orcid":false,"given":"Bianca","family":"Barreira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Paternoster","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-4633","authenticated-orcid":false,"given":"Daniel","family":"Morales-Cano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-8191","authenticated-orcid":false,"given":"Miguel A.","family":"Olivencia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-2841","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Quintana-Villamandos","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-4011","authenticated-orcid":false,"given":"Diego A.","family":"Rodr\u00edguez-Chiarad\u00eda","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"IMIM-Hospital del Mar","place":["Spain"]},{"name":"Universitat Pompeu Fabra, Barcelona Biomedical Research Park","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-1698","authenticated-orcid":false,"given":"Angel","family":"Cogolludo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-7418","authenticated-orcid":false,"given":"Francisco","family":"Perez-Vizcaino","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02p0gd045","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Complutense de Madrid","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (Ciberes)","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01887-2018"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13968"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020448"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180615"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-1011-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.4.6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0312-5"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00475.2019"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1212"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01889-2018"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30532-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01204-2021"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/JP276054"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060795"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0001LE"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.73"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03971"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031316"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2174\/1874306400903010053"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2023.11.006"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00319.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:38:34Z","timestamp":1744803514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00319.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,1]]}},"alternative-id":["10.1152\/ajplung.00319.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00319.2024","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"assertion":[{"value":"2024-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}