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Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.<\/jats:p>","DOI":"10.1152\/ajplung.00325.2017","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:10:47Z","timestamp":1503619847000},"page":"L1096-L1100","source":"Crossref","is-referenced-by-count":80,"title":["Epigenetic changes by DNA methylation in chronic and intermittent hypoxia"],"prefix":"10.1152","volume":"313","author":[{"given":"Jayasri","family":"Nanduri","sequence":"first","affiliation":[{"name":"Institute For Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, The University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg 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