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P. aeruginosa included in agarose beads was then instilled intratracheally, and the animals were studied for 7 days. On the 4th day, the mice fed with the \u03c9-3 diet had a higher lean body mass gain and a lower \u03c9-6:\u03c9-3 ratio of fatty acids extracted from the lung tissue compared with the other groups ( P &lt; 0.05). The \u03c9-3 group had the lowest mortality. Distal alveolar fluid clearance (DAFC) as well as the inflammatory response and the cellular recruitment were higher in the \u03c9-3 group on the 4th day. The effect on DAFC was independent of \u03b1-epithelial Na<jats:sup>+<\/jats:sup>channels (\u03b1-ENaC), \u03b2-ENaC, and \u03b1<jats:sub>1<\/jats:sub>-Na-K-ATPase mRNA expressions, which were not altered by the different diets. In conclusion, a diet enriched in \u03c9-3 PUFA can change lung membrane composition and improve survival in chronic pneumonia. This effect on survival is probably multifactorial involving the increased DAFC capacity as well as the optimization of the initial inflammatory response. This work suggests that a better control of the \u03c9-6\/\u03c9-3 PUFA balance may represent an interesting target in the prevention and\/or control of P. aeruginosa infection in patients.<\/jats:p>","DOI":"10.1152\/ajplung.00337.2006","type":"journal-article","created":{"date-parts":[[2007,2,24]],"date-time":"2007-02-24T03:36:30Z","timestamp":1172288190000},"page":"L1422-L1431","source":"Crossref","is-referenced-by-count":44,"title":["Omega-3 polyunsaturated fatty acids improve host response in chronic<i>Pseudomonas aeruginosa<\/i>lung infection in mice"],"prefix":"10.1152","volume":"292","author":[{"given":"Maud","family":"Pierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Husson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozenn Le","family":"Berre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Desseyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Galabert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"B\u00e9ghin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Beermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Dagenais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Berthiaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Cardinaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Barbry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Gottrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet P.","family":"Guery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.7.4263-4271.2005"},{"key":"R2","unstructured":"Berthiaume Y.Mechanisms of edema clearance. 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