{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:16:57Z","timestamp":1783696617209,"version":"3.55.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100013329","name":"National Sanitarium Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013329","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Quebec Respiratory Health Research Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p>Genetic predispositions and environmental exposures are regarded as the main predictors of respiratory disease development. Although the impact of dietary essential nutrient deficiencies on cardiovascular disease, obesity, and type II diabetes has been widely studied, it remains poorly explored in chronic respiratory diseases. Dietary choline and methionine deficiencies are common in the population, and their impact on pulmonary homeostasis is currently unknown. Mice were fed choline- and\/or methionine-deficient diets while being exposed to room-air or cigarette smoke for up to 4 wk. Lung functions were assessed using the FlexiVent. Pulmonary transcriptional activity was assessed using gene expression microarrays and quantitative PCR. Immune cells, cytokines, and phosphatidylcholine were quantified in the bronchoalveolar lavage. In this study, we found that short-term dietary choline and\/or methionine deficiencies significantly affect lung function in mice in a reversible manner. It also reduced transcriptional levels of collagens and elastin as well as pulmonary surfactant phosphatidylcholine levels. We also found that dietary choline and\/or methionine deficiencies markedly interfered with the pulmonary response to cigarette smoke exposure, modulating lung function and dampening inflammation. These findings clearly show that dietary choline and\/or methionine deficiencies can have dramatic pathophysiological effects on the lungs and can also affect the pathobiology of cigarette smoke-induced pulmonary alterations. Expanding our knowledge in the field of \u201cnutri-respiratory research\u201d may reveal a crucial role for essential nutrients in pulmonary health and disease, which may prove to be as relevant as genetic predispositions and environmental exposures.<\/jats:p>","DOI":"10.1152\/ajplung.00353.2019","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T01:35:35Z","timestamp":1594258535000},"page":"L391-L402","source":"Crossref","is-referenced-by-count":8,"title":["Critical importance of dietary methionine and choline in the maintenance of lung homeostasis during normal and cigarette smoke exposure conditions"],"prefix":"10.1152","volume":"319","author":[{"given":"\u00c9ric","family":"Jubinville","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Laval, Quebec City, Canada"},{"name":"Quebec Heart and Lung Institute, Universit\u00e9 Laval, Quebec City, 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