{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:33Z","timestamp":1787314173484,"version":"build-2736575974"},"reference-count":56,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR 4446\/3-1"],"award-info":[{"award-number":["GR 4446\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>Mechanical ventilation is frequently used in critically ill patients and can itself cause pulmonary damage. Furthermore, hemolysis is common in sepsis and ARDS. Mice receiving mechanical ventilation and an infusion of cell-free hemoglobin (CFH) demonstrated increased impairment of lung mechanics associated with lung edema not fully explainable by the proinflammatory and proedematous effects of CFH. Furthermore, increased plasma concentrations of CFH correlated with reduced pulmonary compliance in patients with severe ARDS and therapy with ECMO.<\/jats:p>","DOI":"10.1152\/ajplung.00355.2025","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:20:59Z","timestamp":1777566059000},"page":"L696-L707","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravascular hemolysis aggravates ventilator-induced lung injury in mice"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-3866","authenticated-orcid":false,"given":"Maximilian","family":"Buttenberg","sequence":"first","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-2423","authenticated-orcid":false,"given":"Victoria","family":"B\u00fcnger","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Taher","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"H\u00f6fer","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-0131","authenticated-orcid":false,"given":"Helen","family":"Rinderknecht","sequence":"additional","affiliation":[{"name":"Ulm University Medical Center","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borna","family":"Relja","sequence":"additional","affiliation":[{"name":"Ulm University Medical Center","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klopfleisch","sequence":"additional","affiliation":[{"name":"Freie Universit\u00e4t Berlin","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-9364","authenticated-orcid":false,"given":"Roland C. E.","family":"Francis","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]},{"name":"Universit\u00e4tsklinikum Erlangen","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-2961","authenticated-orcid":false,"given":"Wolfgang M.","family":"Kuebler","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6920-8868","authenticated-orcid":false,"given":"Jan A.","family":"Graw","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin","place":["Germany"]},{"name":"Universit\u00e4tsklinikum Erlangen","place":["Germany"]},{"name":"Ulm University","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1410639"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.07.08"},{"key":"B5","first-page":"482","volume":"110","author":"Tremblay LN","year":"1998","journal-title":"Proc Assoc Am Physicians"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1092878"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001118"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182741a54"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00340"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00155.2015"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03894-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010245"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061697"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1787"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.392"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-015-0086-3"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000356"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-023-00664-5"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.729137"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.008698"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39115"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59770"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-2058OC"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00851.2016"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s003950070029"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181962ce6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1228476"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1127OC"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1086\/654929"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-245001"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-371849"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2385-z"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98546"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-021-00387-7"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019955"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.24"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0850OC"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nm1499"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00131.2020"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00123.2023"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228727"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-015-0069-7"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1090773"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024942132705"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2403-1"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143527"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124034"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.50217"},{"key":"B49","unstructured":"Extracorporeal Life Support Organization. ELSO Registry Data Definitions (Online). Extracorporeal Life Support Organization. https:\/\/www.elso.org\/Portals\/0\/Files\/PDF\/ELSO%20Registry%20Data%20Definitions%2005_17_22.pdf [2026 Jan 29]."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2008"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123013"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-539353"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174508"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181760e5d"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4605"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2012.12.007"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00355.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:32:05Z","timestamp":1782149525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00355.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajplung.00355.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00355.2025","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}