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We used the mouse macrophage cell line RAW 264.7 because these cells are resistant to apoptosis, have high proliferative capacity, and resemble cells in the plexiform lesions that tend to pile up instead of maintaining a monolayer. Cells were characterized by immunocytochemistry with cell surface markers ( Lycopersicon Esculentum Lectin, CD117, CD133, FVIII, CD31, VEGFR-2, and S100). Activated, but not quiescent, T cells were able to suppress RAW 264.7 cell proliferative and migration activity in vitro. The carboxyfluorescein diacetate-labeled RAW 264.7 cells were injected into the na\u00efve Sprague Dawley (SD) rat and athymic nude rat. Twelve days later, cells were found in the lung vasculature of athymic nude rats that lack functional T cells, contributing to vascular remodeling. No labeled RAW 264.7 cells were detected in the lungs of immune-competent SD rats. Our data demonstrate that T cells can inhibit in vitro migration and in vivo accumulation of macrophage-like cells. <\/jats:p>","DOI":"10.1152\/ajplung.00357.2011","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T12:04:10Z","timestamp":1330949050000},"page":"L1014-L1022","source":"Crossref","is-referenced-by-count":24,"title":["Interplay of macrophages and T cells in the lung vasculature"],"prefix":"10.1152","volume":"302","author":[{"given":"Evgenia","family":"Gerasimovskaya","sequence":"first","affiliation":[{"name":"Department of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, 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