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We previously showed in mice how Atm was required to mount a protective immune memory response to influenza A virus [IAV; Hong Kong\/X31 (HKx31), H3N2]. Here, Atm wildtype (WT) and knockout (Atm-null) mice were used to investigate how Atm is required to regenerate the injured airway epithelium following IAV infection. When compared with WT mice, naive Atm-null mice had increased airway resistance and reduced lung compliance that worsened during infection before returning to na\u00efve levels by 56 days postinfection (dpi). Although Atm-null lungs appeared pathologically normal before infection by histology, they developed an abnormal proximal airway epithelium after infection that contained E-cadherin<jats:sup>+<\/jats:sup>, Sox2<jats:sup>+<\/jats:sup>, and Cyp2f2<jats:sup>+<\/jats:sup> cells lacking secretoglobin family 1 A member 1 (Scgb1a1) protein expression. Patchy and low expression of Scgb1a1 were eventually observed by 56 dpi. Genetic lineage tracing in HKx31-infected mice revealed club cells require Atm to rapidly and efficiently restore Scgb1a1 expression in proximal airways. Since Scgb1a1 is an immunomodulatory protein that protects the lung against a multitude of respiratory challenges, failure to efficiently restore its expression may contribute to the respiratory diseases seen in individuals with ataxia telangiectasia. <\/jats:p>","DOI":"10.1152\/ajplung.00378.2021","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T02:49:08Z","timestamp":1645670948000},"page":"L581-L592","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection"],"prefix":"10.1152","volume":"322","author":[{"given":"Rachel","family":"Warren","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and         Dentistry, University of Rochester, Rochester, New 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