{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:10:40Z","timestamp":1787735440042,"version":"build-2784847793"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation de l'IUCPQ"},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-387910"],"award-info":[{"award-number":["PJT-387910"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["ALLRP 553984-20"],"award-info":[{"award-number":["ALLRP 553984-20"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2020-06355"],"award-info":[{"award-number":["RGPIN-2020-06355"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p> There are renewed interests in using the parameter K of Salazar\u2013Knowles\u2019 equation to assess lung tissue compliance. K either decreases or increases when the lung\u2019s parenchyma stiffens or loosens, respectively. However, whether K is affected by other common features of respiratory diseases, such as inflammation and airway smooth muscle (ASM) contraction, is unknown. Herein, male C57BL\/6 mice were treated intranasally with either saline or lipopolysaccharide (LPS) at 1 mg\/kg to induce pulmonary inflammation. They were then subjected to either a multiple or a single-dose challenge with methacholine to activate ASM to different degrees. A quasi-static pressure-driven partial pressure-volume (P-V) maneuver was performed before and after methacholine. The Salazar\u2013Knowles\u2019 equation was then fitted to the deflation limb of the P-V loop to obtain K, as well as the parameter A, an estimate of lung volume (inspiratory capacity). The fitted curve was also used to derive the quasi-static elastance (E<jats:sub>st<\/jats:sub>) at 5 cmH<jats:sub>2<\/jats:sub>O. The results demonstrate that LPS and both methacholine challenges increased E<jats:sub>st<\/jats:sub>. LPS also decreased A, but did not affect K. In contradistinction, methacholine decreased both A and K in the multiple-dose challenge, whereas it decreased K but not A in the single-dose challenge. These results suggest that LPS increases E<jats:sub>st<\/jats:sub> by reducing the open lung volume (A) and without affecting tissue compliance (K), whereas methacholine increases E<jats:sub>st<\/jats:sub> by decreasing tissue compliance with or without affecting lung volume. We conclude that lung tissue compliance, assessed using the parameter K of Salazar\u2013Knowles\u2019 equation, is insensitive to inflammation but sensitive to ASM contraction. <\/jats:p>","DOI":"10.1152\/ajplung.00384.2021","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T17:29:12Z","timestamp":1640194152000},"page":"L294-L304","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of airway smooth muscle contraction and inflammation on lung tissue compliance"],"prefix":"10.1152","volume":"322","author":[{"given":"Magali","family":"Boucher","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyndi","family":"Henry","sequence":"additional","affiliation":[{"name":"Institut Universitaire de 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