{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:56:48Z","timestamp":1791331008637,"version":"4.3.1"},"reference-count":48,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p>We investigated the development of airway hyperreactivity (AHR) and inflammation in the lungs of nine genetically diverse inbred strains of mice [129\/SvIm, A\/J, BALB\/cJ, BTBR+(T)\/tf\/tf, CAST\/Ei, C3H\/HeJ, C57BL\/6J, DBA\/2J, and FVB\/NJ] after sensitization and challenge with ovalbumin (OVA). At 24, 48, and 72 h post-OVA exposure, the severity of AHR and eosinophilic inflammation of the mouse strains ranged from relatively unresponsive to responsive. The severity of the airway eosinophilia of some strains did not clearly correlate with the development of AHR. The temporal presence of T helper type 2 cytokines in lung lavage fluid also varied markedly among the strains. The levels of IL-4 and IL-13 were generally increased in the strains with the highest airway eosinophilia at 24 and 72 h postexposure, respectively; the levels of IL-5 were significantly increased in most of the strains with airway inflammation over the 72-h time period. The differences of physiological and biological responses among the inbred mouse strains after OVA sensitization and challenge support the hypothesis that genetic factors contribute, in part, to the development of allergen-induced airway disease.<\/jats:p>","DOI":"10.1152\/ajplung.00390.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:21:40Z","timestamp":1425396100000},"page":"L32-L42","source":"Crossref","is-referenced-by-count":145,"title":["Allergen-induced airway disease is mouse strain dependent"],"prefix":"10.1152","volume":"285","author":[{"given":"Gregory S.","family":"Whitehead","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710-0001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K. L.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710-0001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine G.","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710-0001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710-0001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710-0001"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9806034"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.6.1397"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90060-0"},{"key":"REF4","unstructured":"Chiba Y\n                      , Yanagisawa R, and Saai M.\n                      Strain and route differences in airway responsiveness to acetylcholine in mice.\n                      Res Commun Mol Pathol Pharmacol\n                      90\n                      : 169-172, 1995."},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.109"},{"key":"REF6","unstructured":"De Monchy JG\n                      , Kauffman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ, and De Vries K.\n                      Bronchoalveolar eosinophilia during allergen-induced late asthmatic reaction.\n                      Am Rev Respir Dis\n                      131\n                      : 373-376, 1985."},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)38445-0"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.6.9611068"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.36"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.195"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.14.1.8534490"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1990.tb02678.x"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00742.x"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.3.9606031"},{"key":"REF15","doi-asserted-by":"crossref","unstructured":"Herz U\n                      , Braun A, Ruckert R, and Renz H.\n                      Various immunological phenotypes are associated with increased airway responsiveness.\n                      Clin Exp Allergy\n                      28\n                      : 625-634, 1997.","DOI":"10.1046\/j.1365-2222.1998.00280.x"},{"key":"REF16","doi-asserted-by":"crossref","unstructured":"Hogan SP\n                      , Matthaei KI, Young JM, Koskinen A, Young IG, and Foster PS.\n                      A novel T cell-regulated mechanism modulating allergen-induced airway hyperreactivity in BALB\/c mice independently of IL-4 and IL-5.\n                      J Immunol\n                      161\n                      : 1501-1509, 1998.","DOI":"10.4049\/jimmunol.161.3.1501"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119292"},{"key":"REF18","doi-asserted-by":"crossref","unstructured":"Holberg CJ\n                      , Morgan WJ, Wright AL, and Martinez FD.\n                      Differences in familial segregation of FEV1 between asthmatic and nonasthmatic families. Role of a maternal component.\n                      Am J Respir Crit Care Med\n                      158\n                      : 162-169, 1999.","DOI":"10.1164\/ajrccm.158.1.9706117"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9806170"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.3.8810601"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4190"},{"key":"REF22","doi-asserted-by":"crossref","unstructured":"Kay AB\n                      and Durham SR.\n                      T-lymphocytes, allergy and asthma.\n                      Clin Exp Allergy\n                      21\n                      : 17-21, 1991.","DOI":"10.1111\/j.1365-2222.1991.tb01700.x"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20010901)45:1<27::AID-CYTO1141>3.0.CO;2-I"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00098.x"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1038\/362245a0"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1990.258.4.L157"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01047-1"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.219"},{"key":"REF29","doi-asserted-by":"crossref","unstructured":"Lorenz E\n                      , Jones M, Wohlford-Lenane C, Meyer N, Frees K, Arbour NC, and Schwartz DA.\n                      Genes other than TLR-4 are involved in the response to inhaled LPS.\n                      Am J Physiol Lung Cell Mol Physiol\n                      281\n                      : L1106-L1114, 2001.","DOI":"10.1152\/ajplung.2001.281.5.L1106"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14512109"},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9802048"},{"key":"REF32","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103921"},{"key":"REF33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912233412603"},{"key":"REF34","unstructured":"Minty A\n                      , Asselin S, Bensussan A, Shire D, Vita N, Vyakarnam A, Wijdenes J, Ferrara P, and Caput D.\n                      The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes.\n                      Eur Cytokine Netw\n                      8\n                      : 203-213, 1997."},{"key":"REF35","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11020291"},{"key":"REF36","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.9812061"},{"key":"REF37","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.6.8665031"},{"key":"REF38","doi-asserted-by":"crossref","unstructured":"Spry CJ\n                      .\n                      Mechanism of eosinophilia. VI. Eosinophil mobilization.\n                      Cell Tissue Kinet\n                      4\n                      : 365-374, 1971.","DOI":"10.1111\/j.1365-2184.1971.tb01546.x"},{"key":"REF39","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.2.471"},{"key":"REF40","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.2.L394"},{"key":"REF41","doi-asserted-by":"crossref","unstructured":"Tomkinson A\n                      , Kanehiro A, Rabinovitch N, Joetham A, Cieslewicz G, and Gelfand EW.\n                      The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5.\n                      Am J Respir Crit Care Med\n                      160\n                      : 1283-1291, 2001.","DOI":"10.1164\/ajrccm.160.4.9809065"},{"key":"REF42","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9812110"},{"key":"REF43","doi-asserted-by":"publisher","DOI":"10.1186\/rr7"},{"key":"REF44","doi-asserted-by":"crossref","unstructured":"Wills-Karp M\n                      and Ewart SL.\n                      The genetics of allergen-induced airway hyperresponsiveness in mice.\n                      Am J Respir Crit Care Med\n                      156\n                      : S89-S96, 1998.","DOI":"10.1164\/ajrccm.156.4.12-tac-3"},{"key":"REF45","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5397.2258"},{"key":"REF46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01105-1"},{"key":"REF47","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.43"},{"key":"REF48","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.2.9032210"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.00390.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:21:01Z","timestamp":1691493661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.00390.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1152\/ajplung.00390.2002"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00390.2002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1014652.194322","asserted-by":"object"}]},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}