{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:35:21Z","timestamp":1788784521575,"version":"build-2803163510"},"reference-count":68,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K08HL157728"],"award-info":[{"award-number":["K08HL157728"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K23 GM151730-01"],"award-info":[{"award-number":["K23 GM151730-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K HL-165081"],"award-info":[{"award-number":["K HL-165081"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["2T32HL134629-06A1"],"award-info":[{"award-number":["2T32HL134629-06A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["5U24DK137318"],"award-info":[{"award-number":["5U24DK137318"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>High-fat diet obesity is linked to increased lung injury and bronchoalveolar lavage fluid (BALF) fatty acids in a hyperoxic ARDS model. In the present study, obesity not only upregulated intracellular lipids and effectors of fatty acid mitochondrial import but also was associated with downregulated fatty acid oxidation and reduced ATP production in alveolar epithelial type 2 cells after injury. Hyperoxic AEC2 from obese mice had reduced phospholipids, and obese mice had increased BALF surface tension after injury.<\/jats:p>","DOI":"10.1152\/ajplung.00406.2024","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:10:10Z","timestamp":1753233010000},"page":"L343-L356","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["High-fat diet obesity exacerbates acute lung injury-induced dysregulation of fatty acid oxidation in alveolar epithelial type 2 cells"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-4016","authenticated-orcid":false,"given":"Eleni","family":"Kallinos","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Pin","family":"Chung","sequence":"additional","affiliation":[{"name":"College of Medicine, National Taiwan University","place":["Taiwan"]},{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-0395","authenticated-orcid":false,"given":"Lisa K.","family":"Torres","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]},{"name":"New York-Presbyterian Hospital\/Weill Cornell Medicine, New York City, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-3440","authenticated-orcid":false,"given":"Divya","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baran","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-1821","authenticated-orcid":false,"given":"Peter","family":"Carmeliet","sequence":"additional","affiliation":[{"name":"KU Leuven, VIB Center for Cancer Biology","place":["Belgium"]},{"name":"Khalifa University of Science and Technology","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]},{"name":"New York-Presbyterian Hospital\/Weill Cornell Medicine, New York City, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather W.","family":"Stout-Delgado","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4836-305X","authenticated-orcid":false,"given":"Augustine M. K.","family":"Choi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]},{"name":"New York-Presbyterian Hospital\/Weill Cornell Medicine, New York City, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6191-8921","authenticated-orcid":false,"given":"Maria","family":"Plataki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]},{"name":"New York-Presbyterian Hospital\/Weill Cornell Medicine, New York City, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2021.05.001"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3596"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2010.12.003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2011.00864.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.117572"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5241-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu373"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1457-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00054-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7326\/M20-3214"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7326\/M20-2730"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00089-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257891"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127823"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.10.025"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/rr36"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.041807.123500"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201606069"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142434"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(83)90307-7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105045"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.540260"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51683-1"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52042-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1160440"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0181OC"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2736"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00282"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.4.588"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073358"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0341RC"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.642717"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.655837"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/s0925-4439(98)00061-1"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2016.08.003"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.25.6.4616"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.09.010"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201411-507FR"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38061"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117988108"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nature14362"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03569-1"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.08.005"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22140"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.7326\/M20-3742"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000478"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202308-1321OC"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202401-0213ED"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88097-8"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190632"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0165-2020"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0152OC"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.002"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206868109"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.01.003"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1172\/jci63967"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.036"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02327-2"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0335OC"},{"key":"B61","first-page":"435","volume":"92","author":"Jarc E","year":"2019","journal-title":"Yale J Biol Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/327167"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0038OC"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315833"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2017.6"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046057"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201512-841OC"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00084.2014"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00406.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:25:03Z","timestamp":1757859903000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00406.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.1152\/ajplung.00406.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00406.2024","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"2024-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}