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In another group, rats were treated with anti-neutrophil antiserum \u223c16 h before injury to deplete neutrophils. On day 1 after injury, lung tissue IL-18, neutrophil chemokines (CINC-1\/CINC-3), ICAM-1, neutrophil infiltration, MPO activity, and water content (i.e., edema) were significantly increased in rats receiving a combined insult of EtOH and burn injury compared with rats receiving either EtOH intoxication or burn injury alone. Treatment of rats with caspase-1 inhibitor prevented the increase in lung tissue IL-18, CINC-1, CINC-3, ICAM-1, MPO activity, and edema following EtOH and burn injury. The increase in lung IL-18, MPO, and edema was also prevented in rats treated with anti-IL-18 antibodies. Furthermore, administration of anti-neutrophil antiserum also attenuated the increase in lung MPO activity and edema, but did not prevent the increase in IL-18 levels following EtOH and burn injury. These findings suggest that acute EtOH intoxication before burn injury upregulates IL-18, which in turn contributes to increased neutrophil infiltration. Furthermore, the presence of neutrophils appears to be critical for IL-18-meditaed increased lung tissue edema following a combined insult of EtOH and burn injury. <\/jats:p>","DOI":"10.1152\/ajplung.00408.2006","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T20:48:56Z","timestamp":1168634936000},"page":"L1193-L1201","source":"Crossref","is-referenced-by-count":47,"title":["Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats"],"prefix":"10.1152","volume":"292","author":[{"given":"Xiaoling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Schwacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad H.","family":"Chaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashkoor A.","family":"Choudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(03)00024-8"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00195.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200203000-00001"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00235.2001"},{"key":"R5","unstructured":"Choudhry MA, Gamelli RL, Chaudry IH. 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