{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:52:58Z","timestamp":1784044378268,"version":"3.55.0"},"reference-count":57,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG)","doi-asserted-by":"publisher","award":["AL1632\/2-1"],"award-info":[{"award-number":["AL1632\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG)","doi-asserted-by":"publisher","award":["SFB423"],"award-info":[{"award-number":["SFB423"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"K\u00f6ln Fortune - University Hospital Cologne","award":["245\/2013"],"award-info":[{"award-number":["245\/2013"]}]},{"name":"K\u00f6ln Fortune - University Hospital Cologne","award":["166\/2012"],"award-info":[{"award-number":["166\/2012"]}]},{"DOI":"10.13039\/501100011566","name":"Marga und Walter Boll Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011566","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p> Individuals with intrauterine growth restriction (IUGR) are at risk for chronic lung disease. Using a rat model, we showed in our previous studies that altered lung structure is related to IL-6\/STAT3 signaling. As neuropeptide Y (NPY), a coneurotransmitter of the sympathetic nervous system, regulates proliferation and immune response, we hypothesized that dysregulated NPY after IUGR is linked to IL-6, impaired myofibroblast function, and alveolar growth. IUGR was induced in rats by isocaloric low-protein diet; lungs were analyzed on embryonic day (E) 21, postnatal day (P) 3, P12, and P23. Finally, primary neonatal lung myofibroblasts (pnF) and murine embryonic fibroblasts (MEF) were used to assess proliferation, apoptosis, migration, and IL-6 expression. At E21, NPY and IL-6 expression was decreased, and AKT\/PKC and STAT3\/AMPK\u03b1 signaling was reduced. Early reduction of NPY\/IL-6 was associated with increased chord length in lungs after IUGR at P3, indicating reduced alveolar formation. At P23, however, IUGR rats exhibited a catch-up of body weight and alveolar growth coupled with more proliferating myofibroblasts. These structural findings after IUGR were linked to activated NPY\/PKC, IL-6\/AMPK\u03b1 signaling. Complementary, IUGR-pnF showed increased survival, impaired migration, and reduced IL-6 compared with control-pnF (Co-pnF). In contrast, NPY induced proliferation, migration, and increased IL-6 synthesis in fibroblasts. Additionally, NPY<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed reduced IL-6 signaling and less proliferation of lung fibroblasts. Our study presents a novel role of NPY during alveolarization: NPY regulates 1) IL-6 and lung STAT3\/AMPK\u03b1 signaling, and 2) proliferation and migration of myofibroblasts. These new insights in pulmonary neuroimmune interaction offer potential strategies to enable lung growth. <\/jats:p>","DOI":"10.1152\/ajplung.00432.2016","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:20:16Z","timestamp":1496362816000},"page":"L491-L506","source":"Crossref","is-referenced-by-count":17,"title":["Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction"],"prefix":"10.1152","volume":"313","author":[{"given":"Chansutha","family":"Thangaratnarajah","sequence":"first","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Dinger","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Vohlen","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"},{"name":"University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Klaudt","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Nawabi","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lopez Garcia","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazyna","family":"Kwapiszewska","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dobner","sequence":"additional","affiliation":[{"name":"Experimental Therapy, Preclinical Centre, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai D.","family":"N\u00fcsken","sequence":"additional","affiliation":[{"name":"University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"van Koningsbruggen-Rietschel","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von H\u00f6rsten","sequence":"additional","affiliation":[{"name":"Experimental Therapy, Preclinical Centre, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"D\u00f6tsch","sequence":"additional","affiliation":[{"name":"University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Alejandre Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics, Experimental Pulmonology, University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"},{"name":"University Hospital for Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.379"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1670"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.197657"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00050.2006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026371"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0860-9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9544-7"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.08.005"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.147967"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81270-2"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.069"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.108858"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12751"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0952-0600(88)90003-8"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.202804"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/srep24168"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.164020"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.066712"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000313024"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1159\/000334900"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.113175"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.6906"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00645"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.38"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20783"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00183.2010"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06306.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12781"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0897OC"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.6.1578"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302470"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81389"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu123"},{"key":"B34","first-page":"89","volume":"40","author":"Lubis AR","year":"2008","journal-title":"Acta Med Indones"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.6"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.05.009"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1109"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000106314.99930.65"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.124255"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02435.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1856-z"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-273953"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00008.2009"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001966"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000400006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308922"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00197.2011"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7319.2007"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0752464.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0698"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12757"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13378"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2174\/156802607782341046"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00071.2011"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00070.2015"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60711-5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.2.187"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.00432.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T23:28:51Z","timestamp":1589758131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.00432.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,1]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9,1]]}},"alternative-id":["10.1152\/ajplung.00432.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00432.2016","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,1]]}}}