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We compared the responses to 100% O<jats:sub>2<\/jats:sub> of NB IL-6 and IL-13 transgenic mice with wild-type littermate controls by evaluating mortality, lung tissue TUNEL staining, and mRNA expression using RT-PCR. We used ELISA to measure IL-6 levels in tracheal aspirates from human neonates. Our results show that, in contrast to the cytoprotective effects in mature mice, IL-6 caused significantly increased mortality, DNA injury, caspases, cell death regulator and angiogenic factor expression in hyperoxia in the NB. Furthermore, tracheal aspirate levels of IL-6 were significantly increased in premature neonates with respiratory distress syndrome who had an adverse outcome (bronchopulmonary dysplasia\/death). In contrast to the protective effects in adults, there was no survival advantage to the NB IL-13 mice in hyperoxia. These findings imply that caution should be exercised in extrapolating results from the adult to the NB. <\/jats:p>","DOI":"10.1152\/ajplung.00434.2006","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T20:34:53Z","timestamp":1175286893000},"page":"L142-L150","source":"Crossref","is-referenced-by-count":69,"title":["Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia"],"prefix":"10.1152","volume":"293","author":[{"given":"Rayman","family":"Choo-Wing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Nedrelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Homer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Ben-Ari J, Makhoul IR, Dorio RJ, Buckley S, Warburton D, Walker SM. 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