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Although the lung is dominated by these elements, diabetes is expected to modify the airway function and respiratory tissue mechanics. Therefore, we characterized the respiratory function in patients with diabetes with and without associated obesity. Mechanically ventilated patients with normal body shapes were divided into the control nondiabetic ( n = 73) and diabetic ( n = 31) groups. The other two groups included obese patients without diabetes ( n = 43) or with diabetes ( n = 30). The mechanical properties of the respiratory system were determined by forced oscillation technique. Airway resistance (Raw), tissue damping (G), and tissue elastance (H) were assessed by forced oscillation. Capnography was applied to determine phase 3 slopes and dead space indices. The intrapulmonary shunt fraction (Qs\/Qt) and the lung oxygenation index (Pa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>\/FI<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>) were estimated from arterial and central venous blood samples. Compared with the corresponding control groups, diabetes alone increased the Raw (7.6\u2009\u00b1\u20096 cmH<jats:sub>2<\/jats:sub>O.s\/l vs. 3.1\u2009\u00b1\u20091.9 cmH<jats:sub>2<\/jats:sub>O.s\/l), G (11.7\u2009\u00b1\u20095.5 cmH<jats:sub>2<\/jats:sub>O\/l vs. 6.5\u2009\u00b1\u20092.8 cmH<jats:sub>2<\/jats:sub>O\/l), and H (31.5\u2009\u00b1\u200911.8 cmH<jats:sub>2<\/jats:sub>O\/l vs. 24.2\u2009\u00b1\u20097.2 cmH<jats:sub>2<\/jats:sub>O\/l ( P &lt; 0.001 for all). Diabetes increased the capnographic phase 3 slope, whereas Pa<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>\/FI<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> or Qs\/Qt was not affected. Obesity alone caused similar detrimental changes in respiratory mechanics and alveolar heterogeneity, but these alterations also compromised gas exchange. We conclude that diabetes-induced intrinsic mechanical abnormalities are counterbalanced by hypoxic pulmonary vasoconstriction, which maintained intrapulmonary shunt fraction and oxygenation ability of the lungs. <\/jats:p>","DOI":"10.1152\/ajplung.00439.2020","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T22:49:49Z","timestamp":1606949389000},"page":"L368-L376","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Obesity and diabetes: similar respiratory mechanical but different gas exchange defects"],"prefix":"10.1152","volume":"320","author":[{"given":"Roberta","family":"S\u00fcdy","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, University of Szeged, Szeged, Hungary"},{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, 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