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At 1.5 atmosphere absolute (ATA) and below, the well-recognized pattern of diffuse pulmonary damage developed slowly with an extensive inflammatory response and destruction of the alveolar-capillary barrier leading to edema, impaired gas exchange, respiratory failure, and death; the severity of these effects increased with time over the 56-h period of observation. At higher inspired O\n                    <jats:sub>2<\/jats:sub>\n                    pressures, 2\u20133 ATA, pulmonary injury was greatly accelerated but less inflammatory in character, and events in the brain were a prelude to a distinct lung pathology. The CNS-mediated component of this lung injury could be attenuated by selective inhibition of neuronal nitric oxide synthase (nNOS) or by unilateral transection of the vagus nerve. We propose that extrapulmonary, neurogenic events predominate in the pathogenesis of acute pulmonary oxygen toxicity in hyperbaric oxygenation, as nNOS activity drives lung injury by modulating the output of central autonomic pathways.\n                  <\/jats:p>","DOI":"10.1152\/ajplung.00450.2006","type":"journal-article","created":{"date-parts":[[2007,4,6]],"date-time":"2007-04-06T20:24:48Z","timestamp":1175891088000},"page":"L229-L238","source":"Crossref","is-referenced-by-count":63,"title":["Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide"],"prefix":"10.1152","volume":"293","author":[{"given":"Ivan T.","family":"Demchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Welty-Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry W.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude A.","family":"Piantadosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Arkovitz M\n                      , Szabo C, Garcia V, Wong H, Wispe J.\n                      Differential effects of hyperoxia on the inducible and constitutive isoforms of nitric oxide synthase in the lung.\n                      Shock\n                      5\n                      : 345\u2013350, 1997.","DOI":"10.1097\/00024382-199705000-00006"},{"key":"R2","unstructured":"Balentine JD\n                      .\n                      Pathology of Oxygen Toxicity\n                      . 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