{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:36:40Z","timestamp":1769107000039,"version":"3.49.0"},"reference-count":12,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004158","name":"Marcus Wallenbergs Stiftelse f\u00f6r Internationellt Vetenskapligt Samarbete","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004158","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:p> Acute respiratory distress syndrome (ARDS) is a common cause of death in the intensive care unit, with mortality rates of ~30\u201340%. To reduce invasive diagnostics such as bronchoalveolar lavage and time-consuming in-hospital transports for imaging diagnostics, we hypothesized that particle flow rate (PFR) pattern from the airways could be an early detection method and contribute to improving diagnostics and optimizing personalized therapies. Porcine models were ventilated mechanically. Lipopolysaccharide (LPS) was administered endotracheally and in the pulmonary artery to induce ARDS. PFR was measured using a customized particles in exhaled air (PExA 2.0) device. In contrast to control animals undergoing mechanical ventilation and receiving saline administration, animals who received LPS developed ARDS according to clinical guidelines and histologic assessment. Plasma levels of TNF-\u03b1 and IL-6 increased significantly compared with baseline after 120 and 180 min, respectively. On the other hand, the PFR significantly increased and peaked 60 min after LPS administration, i.e., ~30 min before any ARDS stage was observed with other well-established outcome measurements such as hypoxemia, increased inspiratory pressure, and lower tidal volumes or plasma cytokine levels. The present results imply that PFR could be used to detect early biomarkers or as a clinical indicator for the onset of ARDS. <\/jats:p>","DOI":"10.1152\/ajplung.00524.2019","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T09:22:56Z","timestamp":1580289776000},"page":"L510-L517","source":"Crossref","is-referenced-by-count":24,"title":["Increased particle flow rate from airways precedes clinical signs of ARDS in a porcine model of LPS-induced acute lung injury"],"prefix":"10.1152","volume":"318","author":[{"given":"Martin","family":"Stenlo","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Sk\u00e5ne University Hospital, Lund University, Lund, Sweden"},{"name":"Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snejana","family":"Hyll\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Sk\u00e5ne University Hospital, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iran A. N.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden"},{"name":"Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden"},{"name":"Lund Stem Cell Center, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz A.","family":"B\u00f6l\u00fckbas","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden"},{"name":"Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden"},{"name":"Lund Stem Cell Center, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Pierre","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Sk\u00e5ne University Hospital, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Hallgren","sequence":"additional","affiliation":[{"name":"Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-1309","authenticated-orcid":false,"given":"Darcy E.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden"},{"name":"Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden"},{"name":"Lund Stem Cell Center, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4484-6473","authenticated-orcid":false,"given":"Sandra","family":"Lindstedt","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care and Cardiothoracic Surgery and Transplantation, Sk\u00e5ne University Hospital, Lund University, Lund, Sweden"},{"name":"Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-0970-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1491"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-019-0231-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-018-0188-z"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21907"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"B7","first-page":"1009","volume":"2","author":"Gonzales JN","year":"2015","journal-title":"Austin J Vasc Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407697-6.00004-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01225-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F305"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2015.06.001"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.00524.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T17:33:06Z","timestamp":1582738386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.00524.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,1]]}},"alternative-id":["10.1152\/ajplung.00524.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00524.2019","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,1]]}}}