{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:26:58Z","timestamp":1788211618224,"version":"build-2803163510"},"reference-count":32,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health (OER)","doi-asserted-by":"publisher","award":["R01HL119280"],"award-info":[{"award-number":["R01HL119280"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health (OER)","doi-asserted-by":"publisher","award":["R01HD0888033"],"award-info":[{"award-number":["R01HD0888033"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:p> We previously showed that the thioredoxin reductase-1 (TrxR1) inhibitor aurothioglucose (ATG) improves alveolarization in hyperoxia-exposed newborn C3H\/HeN mice. Our data supported a mechanism by which the protective effects of ATG are mediated via sustained nuclear factor E2-related factor 2 (Nrf2) activation in hyperoxia-exposed C3H\/HeN mice 72 h after ATG administration. Given that inbred mouse strains have differential sensitivity and endogenous Nrf2 activation by hyperoxia, the present studies utilized two C57BL\/6 exposure models to evaluate the effects of ATG on lung development and Nrf2 activation. The first model (0\u201314 days) was used in our C3H\/HeN studies and the 2nd model (4\u201314 days) is well characterized in C57BL\/6 mice. ATG significantly inhibited lung TrxR1 activity in both models; however, there was no effect on parameters of alveolarization in C57BL\/6 mice. In sharp contrast to C3H\/HeN mice, there was no effect of ATG on pulmonary NADPH quinone oxidoreductase-1 ( Nqo1) and heme oxygenase-1 ( Hmox1) at 72 h in either C57BL\/6 model. In conclusion, although ATG inhibited TrxR1 activity in the lungs of newborn C57BL\/6 mice, effects on lung development and sustained Nrf2-dependent pulmonary responses were blunted. These findings also highlight the importance of strain-dependent hyperoxic sensitivity in evaluation of potential novel therapies. <\/jats:p>","DOI":"10.1152\/ajplung.00539.2017","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T08:13:52Z","timestamp":1516868032000},"page":"L736-L742","source":"Crossref","is-referenced-by-count":13,"title":["Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL\/6 models of bronchopulmonary dysplasia"],"prefix":"10.1152","volume":"314","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Neonatal Redox Biology Laboratory, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Neonatal Redox Biology Laboratory, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie B.","family":"Wall","sequence":"additional","affiliation":[{"name":"Neonatal Redox Biology Laboratory, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn","family":"Dunigan","sequence":"additional","affiliation":[{"name":"Neonatal Redox Biology Laboratory, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-3851","authenticated-orcid":false,"given":"Tamas","family":"Jilling","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette K.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent E.","family":"Tipple","sequence":"additional","affiliation":[{"name":"Neonatal Redox Biology Laboratory, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)00129-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(02)00356-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.02.006"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5332"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511972200"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5942"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.1.4536"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.07.024"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4288"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950200306"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141046"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283423e51"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0228OC"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4377"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90487.2008"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2534-3"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.027086"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900010200"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-247221"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-7052-z"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00145.2015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.21"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0670OC"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.12.017"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00268.2015"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199309000-00024"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.67.040403.102229"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5782"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0376OC"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01392.2009"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1901"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-006-0147-9"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.00539.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T03:46:56Z","timestamp":1569296816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.00539.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5,1]]}},"alternative-id":["10.1152\/ajplung.00539.2017"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00539.2017","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,1]]}}}