{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:15:51Z","timestamp":1776233751600,"version":"3.50.1"},"reference-count":102,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["1K99HL119560-01A1"],"award-info":[{"award-number":["1K99HL119560-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["4R00HL119560-03"],"award-info":[{"award-number":["4R00HL119560-03"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["1P01HL091842"],"award-info":[{"award-number":["1P01HL091842"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["10T2TR001983-01"],"award-info":[{"award-number":["10T2TR001983-01"]}]},{"DOI":"10.13039\/100008925","name":"American Asthma Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001024","name":"Roy J Carver Charitable Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>Mainstay therapeutics are ineffective in some people with asthma, suggesting a need for additional agents. In the current study, we used vagal ganglia transcriptome profiling and connectivity mapping to identify compounds beneficial for alleviating airway hyperreactivity (AHR). As a comparison, we also used previously published transcriptome data from sensitized mouse lungs and human asthmatic endobronchial biopsies. All transcriptomes revealed agents beneficial for mitigating AHR; however, only the vagal ganglia transcriptome identified agents used clinically to treat asthma (flunisolide, isoetarine). We also tested one compound identified by vagal ganglia transcriptome profiling that had not previously been linked to asthma and found that it had bronchodilator effects in both mouse and pig airways. These data suggest that transcriptome profiling of the vagal ganglia might be a novel strategy to identify potential asthma therapeutics.<\/jats:p>","DOI":"10.1152\/ajplung.00557.2017","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T11:25:47Z","timestamp":1522927547000},"page":"L133-L148","source":"Crossref","is-referenced-by-count":16,"title":["The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity"],"prefix":"10.1152","volume":"315","author":[{"given":"Leah R.","family":"Reznikov","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, University of Florida, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-3253","authenticated-orcid":false,"given":"David K.","family":"Meyerholz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Abou Alaiwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa"},{"name":"Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ping","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, University of Florida, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Shin J.","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, University of Florida, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas L.","family":"Bormann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Bair","sequence":"additional","affiliation":[{"name":"Iowa Institute of Human Genetics, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa"},{"name":"Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Stoltz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa"},{"name":"Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa"},{"name":"Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"},{"name":"Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa"},{"name":"Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa"},{"name":"Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"},{"name":"Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00497.x"},{"key":"B2","first-page":"1131","volume":"110","author":"Ananth J","year":"1974","journal-title":"Can Med Assoc J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0276OC"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1544-0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01978790"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702779"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201302-0317PP"},{"key":"B8","first-page":"334","volume":"16","author":"Bouvier M","year":"1992","journal-title":"Gastroenterol Clin Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90025-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900591106"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00338.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00057.2009"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12506"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02067.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1960.tb00288.x"},{"key":"B16","first-page":"93","volume":"35","author":"Collipp PJ","year":"1975","journal-title":"Ann Allergy"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95332"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1562OC"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2008.29.3121"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/039463200902200213"},{"key":"B21","first-page":"242","volume":"46","author":"Dhanoa J","year":"1998","journal-title":"J Assoc Physicians India"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.10.015"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1163\/092996397750131937"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32831da8d3"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7281"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2101104"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2016.10.014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/BF02714151"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1378\/chest.58.6.558"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813485099"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.129.5.856"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/srep32353"},{"key":"B34","first-page":"16","volume":"147","author":"Hargreave FE","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-0477.2001.01253.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2772"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i5.1123"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.08.008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(02)79136-2"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.020"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132939"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-73"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1992.tb03216.x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199310000-00022"},{"key":"B45","first-page":"195","volume":"64","author":"Lew DB","year":"1990","journal-title":"Ann Allergy"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.18589"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.145383"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.1.244"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00158.2003"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2017.06.005"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090849"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030467"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198812001-00010"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102133"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-8-90"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1339032"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00729.x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.18.4.3055"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw943"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/0952-0600(91)90017-W"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00259.2013"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/35039512"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842188"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.1.55S"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.831870"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166089"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02670.x"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.12.18396"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku555"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600560924"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.2.0012"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006135"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011259"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198307000-00004"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.03.006"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-065"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2009.1.1.10"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.12.024"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt477"},{"key":"B80","first-page":"49","author":"Smirnov DA","year":"1991","journal-title":"Anesteziol Reanimatol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4618"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.41"},{"key":"B83","first-page":"1203","volume":"91","author":"Sproule BJ","year":"1964","journal-title":"Can Med Assoc J"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14412-1"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000928"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.049"},{"key":"B87","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1183\/09031936.93.03050535","volume":"3","author":"Szczeklik A","year":"1990","journal-title":"Eur Respir J"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.007"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90732-I"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(94)90157-0"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411032111"},{"key":"B92","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1742-1241.1986.tb07977.x","volume":"40","author":"Tudor GJ","year":"1986","journal-title":"Br J Clin Pract"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6382.1934-a"},{"key":"B94","first-page":"301","volume":"253","author":"Ufkes JG","year":"1981","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw993"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185985"},{"key":"B97","first-page":"551","volume":"149","author":"Wingard DL","year":"1988","journal-title":"West J Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04216.x"},{"key":"B99","first-page":"1107","volume":"23","author":"Xie QM","year":"2002","journal-title":"Acta Pharmacol Sin"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00115412"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.12.002"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608018103"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2132"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.00557.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T23:03:16Z","timestamp":1693609396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.00557.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":102,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8,1]]}},"alternative-id":["10.1152\/ajplung.00557.2017"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00557.2017","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}