{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T22:35:36Z","timestamp":1718145336129},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[1992,6,1]]},"abstract":"<jats:p> Surfactant protein A (SP-A) metabolism was studied in vivo in 33 preterm ventilated lambs at 138 +\/- 1 days gestational age by measuring recoveries of exogenously administered surfactant containing both radiolabeled SP-A and labeled saturated phosphatidylcholine (Sat PC) given via the trachea at birth. Endogenously secreted SP-A was also labeled with [35S]methionine and followed over 24 h. The exogenously labeled SP-A left the alveolar pool more rapidly than did Sat PC over the first 5 h of life (P less than 0.05), and both exogenously labeled SP-A and Sat PC were detected within lamellar bodies by 2 h, indicating uptake from the airspaces. The quantity of SP-A in alveolar washes increased about twofold from birth to 5 h of age, whereas alveolar Sat PC pools were constant over 24 h. The SP-A endogenously labeled with [35S]methionine was recovered at highest specific activities in the alveolar washes at 10 and 45 min after birth with no labeled SP-A detectable in lamellar body fractions until 2 h. The curve for endogenous SP-A labeling of lamellar bodies was similar to that for exogenous labeling, indicating that SP-A was initially secreted by a pathway independent of lamellar bodies with subsequent SP-A labeling of lamellar bodies. The kinetics of SP-A metabolism were very different than for Sat PC in preterm lambs. <\/jats:p>","DOI":"10.1152\/ajplung.1992.262.6.l765","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T14:55:37Z","timestamp":1514040937000},"page":"L765-L772","source":"Crossref","is-referenced-by-count":5,"title":["Surfactant protein A metabolism in preterm ventilated lambs"],"prefix":"10.1152","volume":"262","author":[{"given":"M.","family":"Ikegami","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, School of Medicine, Torrance 90509."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, School of Medicine, Torrance 90509."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tabor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, School of Medicine, Torrance 90509."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. D.","family":"Rider","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, School of Medicine, Torrance 90509."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Jobe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, School of Medicine, Torrance 90509."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.1992.262.6.L765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T21:01:13Z","timestamp":1567976473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.1992.262.6.L765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6,1]]}},"alternative-id":["10.1152\/ajplung.1992.262.6.L765"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.1992.262.6.l765","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6,1]]}}}