{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:59:58Z","timestamp":1772895598717,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:p> To evaluate the possible relationship between submucosal glands and transepithelial Cl- secretion, we compared the bioelectric properties of two distal airway regions: bronchioles, which contain few submucosal glands, and small bronchi, which contain numerous glands. Intact distal bronchi were dissected from the lungs of 4-8 wk old pigs and cannulated with micropipettes and perfused. Transepithelial potential difference (PD), short-circuit current (Isc), and barrier resistance (Rm) in distal bronchi, determined by cable analysis, were -3.0 +\/- 0.4 mV, 50.7 +\/- 5.9 microA\/cm2, and 59.6 +\/- 5.9 omega.cm2, respectively (means +\/- SE). Bumetanide (10 microM), which blocks Cl- secretion through inhibition of Na(+)-K(+)-2Cl- cotransport, reduced Isc in distal bronchi by 30.0 +\/- 5.5 microA\/cm2 (59.0% of the total Isc). By comparison, a previous study of porcine distal airways [S.T. Ballard and A.E. Taylor, Am. J. Physiol. 267 (Lung Cell. Mol. Physiol. 11): L79-L84, 1994] determined that bumetamide-sensitive Isc in bronchioles was 2.6 +\/- 1.4 microA\/cm2 (only 9.0% of the total Isc). Submucosal gland duct openings to the luminal surface were identified microscopically and counted in representative fields. In eight bronchioles, 6.8 +\/- 4.4 gland duct openings\/cm2 of airway surface were observed, whereas seven distal bronchi contained 916.8 +\/- 84.0 gland duct openings\/cm2, over a 100-fold difference. These data suggest that a direct relationship may exist between the magnitude of active transepithelial Cl- secretion and the presence of submucosal glands in normal distal airways. <\/jats:p>","DOI":"10.1152\/ajplung.1995.268.3.l526","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T12:59:15Z","timestamp":1514033955000},"page":"L526-L531","source":"Crossref","is-referenced-by-count":14,"title":["Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution"],"prefix":"10.1152","volume":"268","author":[{"given":"S. T.","family":"Ballard","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine, University of SouthAlabama, Mobile 36688."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Fountain","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, University of SouthAlabama, Mobile 36688."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Inglis","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, University of SouthAlabama, Mobile 36688."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Corboz","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, University of SouthAlabama, Mobile 36688."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, University of SouthAlabama, Mobile 36688."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.1995.268.3.L526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:26:45Z","timestamp":1567963605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.1995.268.3.L526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3,1]]}},"alternative-id":["10.1152\/ajplung.1995.268.3.L526"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.1995.268.3.l526","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3,1]]}}}