{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:23:09Z","timestamp":1790760189518,"version":"4.1.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:p> The functional role of interleukin (IL)-4 in the development of airway hyperresponsiveness (AHR) and pulmonary eosinophilia in response to sensitization and challenge of mice with sheep red blood cells (SRBC) was examined. Control- and SRBC-sensitized A\/J mice were treated with an antibody to the murine IL-4 receptor (anti-IL-4R) 3 days before intratracheal challenge with the antigen or vehicle only. Blockade of IL-4R significantly reduced antigen-induced AHR and prevented increases in goblet cells and bronchoalveolar lavage (BAL) eosinophils. Treatment with anti-IL-4R did not affect antigen-induced increases in lung mRNA and BAL protein levels of IL-5 and interferon-gamma or IL-4 mRNA but did significantly increase IL-4 protein levels. Antigen-induced AHR was not reduced by treatment with antibodies to the adhesion molecules, vascular cell adhesion molecule-1 and very late activation antigen-4. Administration of IL-4 over a 7-day period did not increase airway reactivity or induce any changes in BAL cell numbers in naive mice. These results demonstrate that IL-4 is necessary for in vivo development of antigen-induced AHR, goblet cell metaplasia, and pulmonary eosinophilia. <\/jats:p>","DOI":"10.1152\/ajplung.1997.272.2.l253","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T12:28:33Z","timestamp":1514032113000},"page":"L253-L261","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice"],"prefix":"10.1152","volume":"272","author":[{"given":"S. H.","family":"Gavett","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"O'Hearn","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Karp","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. H.","family":"Schofield","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. D.","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wills-Karp","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins UniversitySchool of Hygiene and Public Health, Baltimore, Maryland 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.1997.272.2.L253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:43:48Z","timestamp":1567975428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.1997.272.2.L253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2,1]]}},"alternative-id":["10.1152\/ajplung.1997.272.2.L253"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.1997.272.2.l253","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2,1]]}}}