{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:17:10Z","timestamp":1782955030613,"version":"3.54.5"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p> The primary objective of this study was to test the hypothesis that a catecholamine-dependent mechanism would upregulate alveolar liquid clearance after fluid resuscitation from 15 min of hemorrhagic shock. Anesthetized rats were hemorrhaged to a mean arterial pressure of 35 mmHg for 15 min and were resuscitated with a 4% albumin solution. Alveolar liquid clearance was measured 5 h later by the concentration of protein in the distal airspaces over 1 h after instillation of a 5% albumin solution into one lung. Hemorrhaged rats developed a severe metabolic acidosis that was associated with a significant rise-in plasma epinephrine levels throughout the study. There was a 60% increase in alveolar liquid clearance in hemorrhaged and resuscitated rats compared with control rats. Amiloride (10(-4) or 10(-6) M), propranolol (10(-4) M), or bilateral adrenalectomy inhibited the increase in alveolar liquid clearance. This effect was reproduced by the intravenous administration of epinephrine in adrenalectomized and hemorrhaged rats. Thus these data provide evidence for a catecholamine-dependent regulation of sodium transport that protects the airspaces against flooding several hours after fluid resuscitation from hemorrhagic shock. <\/jats:p>","DOI":"10.1152\/ajplung.1997.273.2.l305","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T13:19:01Z","timestamp":1514035141000},"page":"L305-L314","source":"Crossref","is-referenced-by-count":11,"title":["Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats"],"prefix":"10.1152","volume":"273","author":[{"given":"K.","family":"Modelska","sequence":"first","affiliation":[{"name":"Department of Anesthesia, University of California, San Francisco94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Matthay","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, University of California, San Francisco94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"McElroy","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, University of California, San Francisco94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Pittet","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, University of California, San Francisco94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.1997.273.2.L305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:47:19Z","timestamp":1567975639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.1997.273.2.L305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,8,1]]}},"alternative-id":["10.1152\/ajplung.1997.273.2.L305"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.1997.273.2.l305","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,1]]}}}