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Control and CDH lambs had similar pulmonary vasodilator responses to acetylcholine, sodium nitroprusside, zaprinast, and dipyridamole. The ET<jats:sub>A<\/jats:sub>-receptor antagonist BQ-123 caused a significantly greater pulmonary vasodilatation in CDH than in control animals. The ET<jats:sub>B<\/jats:sub>-receptor agonist sarafotoxin 6c induced a biphasic response, with a sustained pulmonary vasoconstriction after a transient pulmonary vasodilatation that was not seen in CDH animals. We conclude that the NO signaling pathway in vivo is intact in experimental CDH. In contrast, ET<jats:sub>A<\/jats:sub>-receptor blockade and ET<jats:sub>B<\/jats:sub>-receptor stimulation significantly differed in CDH animals compared with control animals. Imbalance of ET-1-receptor activation favoring pulmonary vasoconstriction rather than altered NO-mediated pulmonary vasodilatation is likely to account for persistent pulmonary hypertension of the newborn in fetal lambs with a surgically created CDH.<\/jats:p>","DOI":"10.1152\/ajplung.2000.278.5.l923","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T00:34:27Z","timestamp":1514075667000},"page":"L923-L932","source":"Crossref","is-referenced-by-count":26,"title":["ET<sub>A<\/sub>-receptor blockade and ET<sub>B<\/sub>-receptor stimulation in experimental congenital diaphragmatic hernia"],"prefix":"10.1152","volume":"278","author":[{"given":"Bernard","family":"Th\u00e9baud","sequence":"first","affiliation":[{"name":"Service de R\u00e9animation N\u00e9onatale, H\u00f4pital Antoine B\u00e9cl\u00e8re, Universit\u00e9 Paris-Sud, 92140 Clamart;"},{"name":"Service de Physiologie-Explorations Fonctionnelles, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris-Universit\u00e9 Paris V, 75014 Paris;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"de Lagausie","sequence":"additional","affiliation":[{"name":"Service de Physiologie-Explorations Fonctionnelles, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris-Universit\u00e9 Paris V, 75014 Paris;"},{"name":"Service de Chirurgie Visc\u00e9rale P\u00e9diatrique and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Forgues","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Visc\u00e9rale Infantile, Centre Hospitalier Universitaire Montpellier, 34000 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Aigrain","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Visc\u00e9rale P\u00e9diatrique and"},{"name":"Ecole de Chirurgie, Assistance Publique-H\u00f4pitaux de Paris, 75005 Paris; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Mercier","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation P\u00e9diatrique, H\u00f4pital Robert Debr\u00e9, Assistance Publique-H\u00f4pitaux de Paris-Universit\u00e9 Paris VII, 75019 Paris;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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