{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:46:52Z","timestamp":1776530812216,"version":"3.51.2"},"reference-count":18,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:p> To study pulmonary arteriolar vasomotion in control conditions and in the transition to hydraulic edema, changes in subpleural pulmonary arteriolar diameter and perivascular interstitial volume were evaluated in anesthetized spontaneously breathing rabbits. Images of subpleural pulmonary microvessels were recorded in control conditions and for up to 180 min during a 0.5 ml \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 min<jats:sup>\u22121<\/jats:sup> intravenous saline infusion through an intact parietal pleural window. Images were digitized and analyzed with a semiautomatic procedure to determine vessel diameter and perivascular interstitial thickness from which interstitial fluid volume was derived. In control vessels, the diameter of \u223c30-, \u223c50-, and \u223c80-\u03bcm arterioles and the perivascular interstitial thickness were fairly stable. During infusion, the diameter increased maximally by 20% in \u223c30-\u03bcm vessels, was unchanged in \u223c50-\u03bcm vessels, and decreased by 25% in \u223c80-\u03bcm arterioles; the perivascular interstitial volume increased by 54% only around 30-\u03bcm microvessels. In papaverine-treated rabbits, all arterioles dilated and a larger increase in perivascular interstitial thickness was observed. The data suggest that the opposite vasomotor behavior of 30- and 80-\u03bcm arterioles during development of mild edema may represent a local specific response of the pulmonary microcirculation to reduce capillary pressure in the face of an increased transendothelial fluid filtration, thus counteracting progression toward severe edema. <\/jats:p>","DOI":"10.1152\/ajplung.2001.281.6.l1464","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T21:56:19Z","timestamp":1514066179000},"page":"L1464-L1471","source":"Crossref","is-referenced-by-count":13,"title":["Pulmonary microvascular and perivascular interstitial geometry during development of mild hydraulic edema"],"prefix":"10.1152","volume":"281","author":[{"given":"Daniela","family":"Negrini","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina, Chirurgia e Odontoiatria, Universit\u00e0 degli Studi, 20133 Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Candiani","sequence":"additional","affiliation":[{"name":"Dipartimento di Bioingegneria, Politecnico di Milano, 20133 Milan; 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