{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:47:16Z","timestamp":1761896836648,"version":"3.37.3"},"reference-count":46,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["R01-HL104106","R01-HL128388"],"award-info":[{"award-number":["R01-HL104106","R01-HL128388"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p> High dietary sodium intake has been linked to alterations in neurally mediated cardiovascular function, but the effects of high sodium on cardiovagal baroreflex sensitivity (cBRS) in healthy adults are unknown. The purpose of this study was to determine whether high dietary sodium alters cBRS and heart rate variability (HRV) and whether acute intravenous sodium loading similarly alters cBRS and HRV. High dietary sodium (300 mmol\/day, 7 days) was compared with low dietary sodium (20 mmol\/day, 7 days; randomized) in 14 participants (38\u2009\u00b1\u20094 yr old, 23\u2009\u00b1\u20091 kg\/m<jats:sup>2<\/jats:sup> body mass index, 7 women). Acute sodium loading was achieved via a 23-min intravenous hypertonic saline infusion (HSI) in 14 participants (22\u2009\u00b1\u20091 yr old, 23\u2009\u00b1\u20091 kg\/m<jats:sup>2<\/jats:sup> body mass index, 7 women). During both protocols, participants were supine for 5 min during measurement of beat-to-beat blood pressure (photoplethysmography) and R-R interval (ECG). cBRS was evaluated using the sequence method. Root mean square of successive differences in R-R interval (RMSSD) was used as an index of HRV. Serum sodium (137.4\u2009\u00b1\u20090.7 vs. 139.9\u2009\u00b1\u20090.5 meq\/l, P &lt; 0.05), plasma osmolality (285\u2009\u00b1\u20091 vs. 289\u2009\u00b1\u20091 mosmol\/kgH<jats:sub>2<\/jats:sub>O, P &lt; 0.05), cBRS (18\u2009\u00b1\u20092 vs. 26\u2009\u00b1\u20093 ms\/mmHg, P &lt; 0.05), and RMSSD (62\u2009\u00b1\u20096 vs. 79\u2009\u00b1\u200910 ms, P &lt; 0.05) were increased following high-sodium diet intake compared with low-sodium diet intake. HSI increased serum sodium (138.1\u2009\u00b1\u20090.4 vs. 141.1\u2009\u00b1\u20090.5 meq\/l, P &lt; 0.05) and plasma osmolality (286\u2009\u00b1\u20091 vs. 290\u2009\u00b1\u20091 mosmol\/kgH<jats:sub>2<\/jats:sub>O, P &lt; 0.05) but did not change cBRS (26\u2009\u00b1\u20095 vs. 25\u2009\u00b1\u20093 ms\/mmHg, P\u2009= 0.73) and RMSSD (63\u2009\u00b1\u20099 vs. 63\u2009\u00b1\u20098 ms, P\u2009= 0.99). These data suggest that alterations in dietary sodium intake alter cBRS and HRV but that acute intravenous sodium loading does not alter these indexes of autonomic cardiovascular regulation. <\/jats:p>","DOI":"10.1152\/ajpregu.00002.2018","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T16:03:51Z","timestamp":1530115431000},"page":"R688-R695","source":"Crossref","is-referenced-by-count":19,"title":["Alterations in dietary sodium intake affect cardiovagal baroreflex sensitivity"],"prefix":"10.1152","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-4411","authenticated-orcid":false,"given":"Matthew C.","family":"Babcock","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Brian","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied 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