{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:05:42Z","timestamp":1778943942378,"version":"3.51.4"},"reference-count":50,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100006812","name":"Center for Integrated Healthcare, U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["E3343-R"],"award-info":[{"award-number":["E3343-R"]}],"id":[{"id":"10.13039\/100006812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL116579"],"award-info":[{"award-number":["HL116579"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL139451"],"award-info":[{"award-number":["HL139451"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:p> The exercise pressor reflex (EPR), a neurocirculatory control mechanism, is exaggerated in hypertensive humans and rats. Disease-related abnormalities within the afferent arm of the reflex loop, including mechano- and metabosensitive receptors located at the terminal end of group III\/IV muscle afferents, may contribute to the dysfunctional EPR in hypertension. Using control (WKY) and spontaneous hypertensive (SHR) rats, we examined dorsal root ganglion (DRG) gene and protein expression of molecular receptors recognized as significant determinants of the EPR. Twelve lumbar DRGs (6 left, 6 right) were harvested from each of 10 WKY [arterial blood pressure (MAP): 96\u2009\u00b1\u20099 mmHg] and 10 SHR (MAP: 144\u2009\u00b1\u20099 mmHg). DRGs from the left side were used for protein expression (Western blotting; normalized to GAPDH), whereas right-side DRGs (i.e., parallel structure) were used to determine mRNA levels (RNA-sequencing, normalized to TPM). Analyses focused on metabosensitive (ASIC3, Bradykinin receptor B2, EP4, P2X3, TRPv1) and mechanosensitive (Piezo1\/2) receptors. Although Piezo1 was similar in both groups ( P = 0.75), protein expression for all other receptors was significantly higher in SHR compared with WKY. With the exception of a greater Bradykinin-receptor B2 in SHR ( P &lt; 0.05), mRNA expression of all other receptors was not different between groups ( P &gt; 0.18). The higher protein content of these sensory receptors in SHR indirectly supports the previously proposed hypothesis that the exaggerated EPR in hypertension is, in part, due to disease-related abnormalities within the afferent arm of the reflex loop. The upregulated receptor content, combined with normal mRNA levels, insinuates that posttranscriptional regulation of sensory receptor protein expression might be impaired in hypertension. <\/jats:p>","DOI":"10.1152\/ajpregu.00007.2022","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T12:01:04Z","timestamp":1653393664000},"page":"R221-R226","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Gene and protein expression of dorsal root ganglion sensory receptors in normotensive and hypertensive male rats"],"prefix":"10.1152","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-8498","authenticated-orcid":true,"given":"Joshua C.","family":"Weavil","sequence":"first","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah"},{"name":"Department of Internal Medicine, University of Utah, Salt 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