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Among the ergogenic effects of dietary nitrate ([Formula: see text]) supplementation in sedentary healthy subjects, a reduced O<jats:sub>2<\/jats:sub> cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice (BR) supplementation, rich in [Formula: see text], on physiological variables associated with exercise tolerance in adolescents with obesity. In a double-blind, randomized crossover study, 10 adolescents with obesity (8 girls, 2 boys; age\u2009=\u200916\u2009\u00b1\u20091 yr; body mass index\u2009=\u200935.2\u2009\u00b1\u20095.0 kg\/m<jats:sup>2<\/jats:sup>) were tested after 6 days of supplementation with BR (5 mmol [Formula: see text] per day) or placebo (PLA). Following each supplementation period, patients carried out two repetitions of 6-min moderate-intensity CWR exercise and one severe-intensity CWR exercise until exhaustion. Plasma [Formula: see text] concentration was significantly higher in BR versus PLA (108\u2009\u00b1\u200937 vs. 15\u2009\u00b1\u20095 \u03bcM, P &lt; 0.0001). The O<jats:sub>2<\/jats:sub> cost of moderate-intensity exercise was not different in BR versus PLA (13.3\u2009\u00b1\u20091.7 vs. 12.9\u2009\u00b1\u20091.1 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7W<jats:sup>\u22121<\/jats:sup>, P = 0.517). During severe-intensity exercise, signs of a reduced amplitude of the O<jats:sub>2<\/jats:sub> uptake slow component were observed in BR, in association with a significantly longer time to exhaustion (561\u2009\u00b1\u2009198 s in BR vs. 457\u2009\u00b1\u2009101 s in PLA, P = 0.0143). In obese adolescents, short-term dietary [Formula: see text] supplementation is effective in improving exercise tolerance during severe-intensity exercise. This may prove to be useful in counteracting early fatigue and reduced physical activity in this at-risk population. <\/jats:p>","DOI":"10.1152\/ajpregu.00017.2018","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T11:17:07Z","timestamp":1524655027000},"page":"R453-R460","source":"Crossref","is-referenced-by-count":16,"title":["Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents"],"prefix":"10.1152","volume":"315","author":[{"given":"Letizia","family":"Rasica","sequence":"first","affiliation":[{"name":"Institute of Molecular Bioimaging and Physiology, National Research Council, Segrate, Italy"},{"name":"Department of Biomedical Sciences for Health, University of Milan, Milan, 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