{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:34:37Z","timestamp":1770064477328,"version":"3.49.0"},"reference-count":49,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p> Excessive mineralocorticoid receptor (MR) stimulation induces neurohumoral excitation and cardiac and vascular fibrosis. In heart failure (HF) rats, with excessive neurohumoral drive, central infusion of the MR antagonist spironolactone (SL) decreases blood-borne TNF-\u03b1. This study aimed to determine whether DOCA, a precursor of aldosterone, acts centrally to stimulate TNF-\u03b1 production in normal rats. DOCA (5 mg sc daily for 8 days) induced a progressive increase in TNF-\u03b1 beginning on day 3 and increased tissue TNF-\u03b1 in hypothalamus, pituitary, and heart but not in other brain and peripheral tissues harvested on day 9. A continuous intracerebroventricular infusion of SL (100 ng\/h) blocked the plasma TNF-\u03b1 response. Oral SL (1 mg\/kg) blocked the plasma and tissue TNF-\u03b1 responses. Thus DOCA increases TNF-\u03b1 in brain, heart, and blood in normal rats. Activation of brain MR appears to account for the increase in plasma TNF-\u03b1. These findings have important implications for the understanding of pathophysiological states (e.g., HF, hypertension) characterized by high circulating levels of aldosterone. <\/jats:p>","DOI":"10.1152\/ajpregu.00027.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:32:56Z","timestamp":1425396776000},"page":"R1402-R1409","source":"Crossref","is-referenced-by-count":28,"title":["Mineralocorticoids act centrally to regulate blood-borne tumor necrosis factor-\u03b1 in normal rats"],"prefix":"10.1152","volume":"285","author":[{"given":"Joseph","family":"Francis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Beltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Kim","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Felder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00279.2002"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1007\/s000590050024"},{"key":"REF3","unstructured":"Brilla CG and Weber KT. 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