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Bladder function was assessed by cystometry in conscious rats treated by intravenous solifenacin (1 mg\/kg). Subsequently, erectile function was assessed under anesthesia following electrical stimulation of the cavernous nerve in presence of intravenous sildenafil (0.3 mg\/kg). GK rats displayed detrusor overactivity with a significant increase in frequency\/amplitude of nonvoiding contractions during the filling phase, together with an increase in bladder capacity, intercontraction interval, voided volume, and maximal pressure of voiding contraction. Solifenacin significantly decreased parameters characterizing voiding contractions without modifying voiding efficiency. Erectile function in GK rats was markedly impaired and remained so after sildenafil treatment despite a significant improvement. GK rats display both bladder and erectile dysfunctions and respond at least partially to standard-of-care treatments for each disorder, thus representing a suitable model to investigate the pathophysiology and assess the efficacy of new therapeutic agents for Type 2 diabetes-associated bladder and erectile complications.<\/jats:p>","DOI":"10.1152\/ajpregu.00033.2013","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T02:22:06Z","timestamp":1386210126000},"page":"R108-R117","source":"Crossref","is-referenced-by-count":14,"title":["Bladder and erectile dysfunctions in the Type 2 diabetic Goto-Kakizaki rat"],"prefix":"10.1152","volume":"306","author":[{"given":"Stephanie","family":"Oger-Roussel","sequence":"first","affiliation":[{"name":"Pelvipharm, Montigny-le-Bretonneux, France;"},{"name":"Research group EA 4501-SIRIUS, Universit\u00e9 Versailles Saint Quentin en Yvelines, Montigny Le Bretonneux, 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