{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:06:29Z","timestamp":1791086789203,"version":"4.1.0"},"reference-count":40,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:p>Fetal malnutrition is now proposed as a risk factor of later obesity and type II diabetes. We previously analyzed the long-term impact of reduced protein and\/or energy intake strictly limited to the last week of pregnancy in Wistar rats. Three protocols of gestational malnutrition were used: 1) low-protein isocaloric diet (5 instead of 15%) with pair feeding to the mothers receiving the control diet, 2) restricted diet (50% of control diet), and 3) low protein-restricted diet (50% of low-protein diet). Only isolated protein restriction induced a long-term \u03b2-cell mass decrease. In the present study, we used the same protocols of food restriction to analyze their short-term impact (on day 21.5 of pregnancy) on \u03b2-cell mass development. A 50% \u03b2-cell mass decrease was present in the three restricted groups, but low-protein diet, either associated or not to energy restriction, increased fetal \u03b2-cell insulin content. Among all the parameters analyzed to further explain our results, we found that the fetal plasma level of taurine was lowered by low-protein diet and was the main predictor of the fetal plasma insulin level ( r = 0.63, P &lt; 0.01). In conclusion, rat fetuses exposed to protein and\/or energy restriction during the third part of pregnancy have a similar dramatic decrease in \u03b2-cell mass, and their ability to recover \u03b2-cell mass development retardation depends on the type of malnutrition used. Moreover, our results support the hypothesis that taurine might play an important role in fetal \u03b2-cell mass function.<\/jats:p>","DOI":"10.1152\/ajpregu.00037.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:25:34Z","timestamp":1425414334000},"page":"R623-R630","source":"Crossref","is-referenced-by-count":53,"title":["Development of \u03b2-cell mass in fetuses of rats deprived of protein and\/or energy in last trimester of pregnancy"],"prefix":"10.1152","volume":"283","author":[{"given":"Eric","family":"Bertin","sequence":"first","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique-UMR 7059, Universit\u00e9 Paris 7\/D. 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