{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:02:20Z","timestamp":1760061740254},"reference-count":49,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p> The effect of central angiotensin AT<jats:sub>1<\/jats:sub>-receptor blockade on thermoregulation in rats during exercise on a treadmill (18 m\/min, 5% inclination) was investigated. Core (T<jats:sub>b<\/jats:sub>) and skin tail temperatures were measured in rats while they were exercising until fatigue after injection of 2 \u03bcl of losartan (Los; 20 nmol, n = 4; 30 nmol, n = 4; 60 nmol, n = 7), an angiotensin II AT<jats:sub>1<\/jats:sub>-receptor antagonist, or 2 \u03bcl of 0.15 mol\/l NaCl (Sal; n = 15) into the right lateral cerebral ventricle. Body heat rate (BHR), heat storage rate, threshold T<jats:sub>b<\/jats:sub> for tail vasodilation (TT<jats:sub>b<\/jats:sub>V), time to fatigue, and workload were calculated. During exercise, the BHR and heat storage rate of Los-treated animals were, respectively, 40 and 53% higher ( P &lt; 0.01) than in Sal-treated animals. Additionally, rats injected with Los showed an increased TT<jats:sub>b<\/jats:sub>V (38.59 \u00b1 0.19\u00b0C for Los vs. 38.12 \u00b1 0.1\u00b0C for Sal, P &lt; 0.02), a higher T<jats:sub>b<\/jats:sub> at fatigue point (39.07 \u00b1 0.14\u00b0C Los vs. 38.66 \u00b1 0.07\u00b0C Sal, P &lt; 0.01), and a reduced running performance (27.29 \u00b1 4.48 min Los vs. 52.47 \u00b1 6.67 min Sal, P &lt; 0.01), which was closely related to the increased BHR. Our data suggest that AT<jats:sub>1<\/jats:sub>-receptor blockade attenuates heat dissipation during exercise due to the higher TT<jats:sub>b<\/jats:sub>V, leading to a faster exercise-induced increase in T<jats:sub>b<\/jats:sub>, thus decreasing running performance. <\/jats:p>","DOI":"10.1152\/ajpregu.00038.2006","type":"journal-article","created":{"date-parts":[[2006,4,14]],"date-time":"2006-04-14T00:55:30Z","timestamp":1144976130000},"page":"R603-R607","source":"Crossref","is-referenced-by-count":23,"title":["Central angiotensin AT<sub>1<\/sub>-receptor blockade affects thermoregulation and running performance in rats"],"prefix":"10.1152","volume":"291","author":[{"given":"Laura H. 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