{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:40:12Z","timestamp":1791214812629,"version":"4.1.0"},"reference-count":34,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL-093167"],"award-info":[{"award-number":["HL-093167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL-127071"],"award-info":[{"award-number":["HL-127071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL-083947"],"award-info":[{"award-number":["HL-083947"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL-130339"],"award-info":[{"award-number":["HL-130339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["20160072"],"award-info":[{"award-number":["20160072"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["15SDG25080095"],"award-info":[{"award-number":["15SDG25080095"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:p> Evidence from animal studies indicates that hyperinsulinemia, without changes in glucose, increases ventilation via a carotid body-mediated mechanism. However, whether insulin elevates ventilation in humans independently of changes in glucose remains unclear. Therefore, we tested the hypothesis that insulin increases ventilation in humans during a hyperinsulinemic-euglycemic clamp in which insulin was elevated to postprandial concentrations while glucose was maintained at fasting concentrations. First, in 16 healthy young men ( protocol 1), we retrospectively analyzed respiration rate and estimated tidal volume from a pneumobelt to calculate minute ventilation during a hyperinsulinemic-euglycemic clamp. In addition, for a direct assessment of minute ventilation during a hyperinsulinemic-euglycemic clamp, we retrospectively analyzed breath-by-breath respiration rate and tidal volume from inspired\/expired gasses in an additional 23 healthy young subjects ( protocol 2). Clamp infusion elevated minute ventilation from baseline in both protocols ( protocol 1: +11.9\u2009\u00b1\u20094.6% baseline, P = 0.001; protocol 2: +9.5\u2009\u00b1\u20093.8% baseline, P = 0.020). In protocol 1, peak changes in both respiration rate (+13.9\u2009\u00b1\u20093.0% baseline, P &lt; 0.001) and estimated tidal volume (+16.9\u2009\u00b1\u20094.1% baseline, P = 0.001) were higher than baseline during the clamp. In protocol 2, tidal volume primarily increased during the clamp (+9.7\u2009\u00b1\u20093.7% baseline, P = 0.016), as respiration rate did not change significantly (+0.2\u2009\u00b1\u20091.8% baseline, P = 0.889). Collectively, we demonstrate for the first time in humans that elevated plasma insulin increases minute ventilation independent of changes in glucose. <\/jats:p>","DOI":"10.1152\/ajpregu.00039.2018","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T11:36:58Z","timestamp":1522237018000},"page":"R84-R89","source":"Crossref","is-referenced-by-count":19,"title":["Insulin increases ventilation during euglycemia in humans"],"prefix":"10.1152","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5776-3824","authenticated-orcid":false,"given":"Thales C.","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of Texas Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Texas Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth W.","family":"Holwerda","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin N.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Physiology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Thyfault","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Joyner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline K.","family":"Limberg","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Fadel","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Texas Arlington, Arlington, 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